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| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 190-439 of human MRPS30. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.89 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2808246 |
Immunogen sequence: PHNPALAAAA LDYRCPVHFY WVRGEEIIPR GHRRGRIDDL RYQIDDKPNN QIRISKQLAE FVPLDYSVPI EIPTIKCKPD KLPLFKRQYE NHIFVGSKTA DPCCYGHTQF HLLPDKLRRE RLLRQNCADQ IEVVFRANAI ASLFAWTGAQ AMYQGFWSEA DVTRPFVSQA VITDGKYFSF FCYQLNTLAL TTQADQNNPR KNICWGTQSK PLYETIEDND VKGFNDDVLL QIVHFLLNRP KEEKSQLLEN; Positive Samples: SW620, HL-60, HeLa, HepG2; Cellular Location: Mitochondrion
Mitochondrial ribosomes consist of a large 39S subunit and a small 28S subunit, both of which are comprised of multiple mitochondrial ribosomal proteins (MRPs) that are encoded by nuclear genes and are essential for protein synthesis within mitochondria. MRP-S30 (mitochondrial ribosomal protein S30), also known as PDCD9 (programmed cell death protein 9), is a 439 amino acid protein that localizes to the mitochondrion, where it exists as a component of the 28S ribosomal subunit and works in conjunction with other MRPs to mediate protein synthesis. MRP-S30 is expressed in kidney, liver, heart and skeletal muscle. The gene encoding MRP-S30 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 28S ribosomal protein S30, mitochondrial; 39S ribosomal protein S30, mitochondrial; Mitochondrial large ribosomal subunit protein mL65; Mitochondrial large ribosomal subunit protein mS30; MRP S30; MRP-S30; programmed cell death 9; Programmed cell death protein 9; S30mt
Gene Aliases: 2610020A16Rik; AA968347; BM-047; MRP-S30; MRPS30; PAP; PDCD9; S30mt
UniProt ID: (Human) Q9NP92, (Mouse) Q9D0G0
Entrez Gene ID: (Human) 10884, (Mouse) 59054, (Rat) 294767
Molecular Function:
ribosomal protein
translational protein
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