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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Full length recombinant MSH2 protein.|
|Storage buffer||0.05M sodium phosphate with 50% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1-2 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||1-2 µg/ml|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-25886 detects MSH2 from human and mouse samples.
PA1-25886 has been successfully used in immunohistochemistry (frozen), immunohistochemistry (paraffin), immunoprecipitation, and Western blot procedures.
The PA1-25886 immunogen is full length recombinant MSH2 protein.
MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
COCA1; DNA mismatch repair protein Msh2; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; mutS homolog 2, colon cancer, nonpolyposis type 1; mutS protein homolog 2
AI788990; COCA1; FCC1; HNPCC; HNPCC1; LCFS2; MSH2