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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 648 and 922 of Human MSH2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-29160 targets MSH2 in WB applications and shows reactivity with Human samples.
The PA5-29160 immunogen is recombinant fragment corresponding to a region within amino acids 648 and 922 of Human MSH2.
MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; mutS homolog 2, colon cancer, nonpolyposis type 1; mutS protein homolog 2
COCA1; FCC1; HNPCC; HNPCC1; LCFS2; MSH2