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Invitrogen

MSH2 Polyclonal Antibody

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MSH2 Polyclonal Antibody

Product Details

PA5-79695

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

Immunocytochemistry (ICC/IF)

2 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived human MSH2 recombinant protein (Position: Q337-N583).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746810

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human K562 whole cell, human SH-SY5Y whole cell, human HEL whole cell, human 293T whole cell, human A549 whole cell, rat PC-12 whole cell, mouse Neuro-2a whole cell. IHC: Human Intestinal Cancer tissue. ICC/IF: U20S cell, SMMC cell. Flow: A431 cell.

Target Information

Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DNA mismatch repair protein Msh2; DNA mismatch repair protein Msh2 transcript; Frameshift mutation results in premature stop; hMSH2; homolog of S. cerevisiae Msh2p [Swiss-Prot accession number P25847] and bacterial MutS proteins [Swiss-Prot accession numbers P23909, P10339, and P27345]; Insertion mutation results in premature stop; mismatch repair protein; Msh2p; mutation causes premature stop; mutS homolog 2, colon cancer, nonpolyposis type 1; MutS protein homolog 2; MutS-like 2; premature stop codon due to mutation; The base insertion results in premature stop; The deletion results in premature stop.; unnamed protein product

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Gene Aliases: AI788990; COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; LYNCH1; MMRCS2; MSH-2; MSH2

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UniProt ID: (Human) P43246, (Mouse) P43247, (Rat) P54275

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Entrez Gene ID: (Human) 4436, (Mouse) 17685, (Rat) 81709

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Function(s)
nucleotide binding magnesium ion binding four-way junction DNA binding DNA binding chromatin binding damaged DNA binding double-stranded DNA binding single-stranded DNA binding protein binding ATP binding enzyme activator activity DNA-dependent ATPase activity ATPase activity centromeric DNA binding mismatched DNA binding guanine/thymine mispair binding dinucleotide insertion or deletion binding single guanine insertion binding single thymine insertion binding dinucleotide repeat insertion binding oxidized purine DNA binding MutLalpha complex binding protein homodimerization activity ADP binding ATP-dependent DNA damage sensor activity Y-form DNA binding heteroduplex DNA loop binding double-strand/single-strand DNA junction binding protein C-terminus binding enzyme binding protein kinase binding single base insertion or deletion binding DNA metabolism protein
Process(es)
in utero embryonic development somatic recombination of immunoglobulin genes involved in immune response oxidative phosphorylation DNA repair mismatch repair postreplication repair double-strand break repair mitotic recombination cellular response to DNA damage stimulus germ cell development determination of adult lifespan male gonad development intrinsic apoptotic signaling pathway in response to DNA damage response to X-ray response to UV-B somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments B cell mediated immunity B cell differentiation intra-S DNA damage checkpoint intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of neuron apoptotic process maintenance of DNA repeat elements isotype switching negative regulation of DNA recombination positive regulation of isotype switching to IgA isotypes positive regulation of isotype switching to IgG isotypes regulation of cell cycle meiotic mismatch repair meiotic gene conversion cell cycle cell cycle arrest reciprocal meiotic recombination negative regulation of reciprocal meiotic recombination positive regulation of helicase activity spermatogenesis response to organic cyclic compound response to drug response to amino acid
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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