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Immunogen sequence: MSRRKPASG GLAASSSAPA RQAVLSRFFQ STGSLKSTSS STGAADQVDP GAAAAAAAAA ATAPPAPPAP AFPPQLPPHI ATEIDRRKKR PLENDGPVKK KVKKVQQKEG GSDLGMSGNS EPKKCLRTRN VSKSLEKLKE FCCDSALPQS RVQTESLQER FAVLPKCTDF DDISLLHAKN AVSSEDSKRQ INQKDTTLFD LSQFGSSNTS HENLQKTASK SANKRSKSIY TPLELQYIEM KQQHKDAVLC VECGYKYRFF GEDAEIAARE LNIYCHLDHN FMTASIPTHR LFVHVRRLVA KGYKVGVVKQ TETAALKAIG DNRSSLFSRK LTALYTKSTL IGEDVNPLIK L (1-350 aa encoded by BC130434)
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Divergent upstream protein; DNA mismatch repair protein Msh3; DUP; hMSH3; Mismatch repair protein 1; MRP1
Gene Aliases: DUC1; DUG; DUP; MRP1; MSH3
UniProt ID: (Human) P20585
Entrez Gene ID: (Human) 4437
Molecular Function: DNA metabolism protein