PA5-29348 targets MSH6 in GS, IF, IHC (P), and WB applications and shows reactivity with Human and Zebrafish samples.
The PA5-29348 immunogen is recombinant fragment corresponding to a region within amino acids 825 and 1110 of Human MSH6.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.
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Protein Aliases: DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; GTMBP; hMSH6; HNPCC5; HSAP; MutS protein homolog 6; MutS-alpha 160 kDa subunit; p160; sperm-associated protein
Gene Aliases: AU044881; AW550279; cb326; GTBP; GTMBP; HNPCC5; HSAP; MSH6; p160; wu:fb36c12