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Invitrogen
MSK2 Polyclonal Antibody
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Product Details
PA5-82821
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RPS6KA4. Recombinant protein control fragment (Product #RP-91470).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AQEVRNHPFF QGLDWVALAA RKIPAPFRPQ IRSELDVGNF AEEFTRLEPV YSPPGSPPPG DPRIFQGYSF VAPSILFDHN NAVMTDGLEA PGAGDRPGRA AVARSAMMQD SPFFQQYELD LREPALGQGS FSVC
Highest antigen sequence indentity to the following orthologs: Rat - 94%, Mouse - 95%.
Target Information
RPS6KA4 (MSK2) is a serine/threonine protein kinase that is essential for the regulation of various cellular processes. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. RPS6KA4 contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 90 kDa ribosomal protein S6 kinase 4; EC 2.7.11.1; kinase MSK2; KS6A4; mitogen- and stress-activated protein kinase 2; Nuclear mitogen- and stress-activated protein kinase 2; Ribosomal protein kinase B; Ribosomal protein S6 kinase alpha-4; ribosomal protein S6 kinase, 90kDa, polypeptide 4; RSKB; S6K-alpha-4; unnamed protein product
Gene Aliases: MSK2; RPS6KA4; RSK-B; S6K-alpha-4
UniProt ID: (Human) O75676
Entrez Gene ID: (Human) 8986
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
ribosomal protein S6 kinase activity
protein binding
ATP binding
kinase activity
transferase activity
histone kinase activity (H3-S10 specific)
histone kinase activity (H3-S28 specific)
metal ion binding
protein serine kinase activity
negative regulation of cytokine production
chromatin remodeling
regulation of transcription, DNA-templated
protein phosphorylation
inflammatory response
positive regulation of CREB transcription factor activity
intracellular signal transduction
TORC1 signaling
post-translational protein modification
positive regulation of transcription from RNA polymerase II promoter
positive regulation of NF-kappaB transcription factor activity
interleukin-1-mediated signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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