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Product Details
24373-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MSL1 Fusion Protein Ag18024 (264-614 aa encoded by BC122543)
Conjugate
Form
Liquid
Concentration
0.32 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MERRMQLVK KDNEKERHKL FQGYETEERE ETELSEKIKL ECQPELSETS QTLPPKPFSC GRSGKGHKRK SPFGSTERKT PVKKLAPEFS KVKTKTPKHS PIKEEPCGSL SETVCKRELR SQETPEKPRS SVDTPPRLST PQKGPSTHPK EKAFSSEIED LPYLSTTEMY LCRWHQPPPS PLPLRESSPK KEETVARCLM PSSVAGETSV LAVPSWRDHS VEPLRDPNPS DLLENLDDSV FSKRHAKLEL DEKRRKRWDI QRIREQRILQ RLQLRMYKKK GIQESEPEVT SFFPEPDDVE SLMITPFLPV VAFGRPLPKL TPQNFELPWL DERSRCRLEI QKKQTPHRTC RK (264-614 aa encoded by BC122543)
Target Information
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Male-specific lethal 1 homolog; Male-specific lethal 1-like 1; Male-specific lethal-1 homolog 1; MSL-1; MSL1-like 1
Gene Aliases: hMSL1; MSL-1; MSL1; MSL1L1
UniProt ID: (Human) Q68DK7
Entrez Gene ID: (Human) 339287
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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