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NeoBiotechnologies
Cytokeratin, pan (Epithelial Marker) Monoclonal Antibody (SPM115, SPM116)
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Product Details
MSM2X-371-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Chicken,
Human,
Mouse,
Non-human primate,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
SPM115, SPM116
Immunogen
Human epidermal keratin
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 39.1; 40-kDa keratin intermediate filament; 47 kDa cytokeratin; 56 kDa cytokeratin; 57kd keratin; 57kDa keratin; 58 kDa cytokeratin; 60-kDa keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; alpha keratin; Cell proliferation-inducing gene 46 protein; CK 2e; CK-1; CK-10; CK-13; CK-14; CK-15; CK-16; CK-17; CK-18; CK-19; CK-1B; CK-2e; CK-2P; CK-3; CK-4; CK-5; CK-6A; CK-6D; CK-7; CK-8; cytokeratin 1; cytokeratin 10; cytokeratin 13; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 2; cytokeratin 3; cytokeratin 4; cytokeratin 5; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin 7; cytokeratin 8; Cytokeratin endo A; Cytokeratin endo B; Cytokeratin otokeratin; cytokeratin type II, component Ia; cytokeratin type II, component Ib/c; cytokeratin type II, component III; Cytokeratin VIB; cytokeratin VII; Cytokeratin-1; Cytokeratin-10; Cytokeratin-13; Cytokeratin-14; Cytokeratin-15; Cytokeratin-16; Cytokeratin-17; Cytokeratin-18; Cytokeratin-19; Cytokeratin-1B; Cytokeratin-2e; Cytokeratin-2P; Cytokeratin-3; Cytokeratin-4; Cytokeratin-5; Cytokeratin-6A; Cytokeratin-6B; Cytokeratin-6D; Cytokeratin-7; Cytokeratin-8; Cytokeratin-A; Cytoskeletal 57 kDa keratin; cytoskeletal protein; ear specific cytokeratin; embryonic type II keratin 1; Embryonic type II keratin-1; Endo B; epidermal keratin 10; epidermal keratin VII; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolysis bullosa simplex, Dowling-Meara, Koebner; epidermolytic hyperkeratosis 1; epidermolytic hyperkeratosis; keratosis palmaris et plantaris; epithelial keratin 1; epithelial keratin 10; epithelial keratin 2e; Epithelial keratin-1; Epithelial keratin-10; Epithelial keratin-2e; focal non-epidermolytic palmoplantar keratoderma; GK-19; Hair alpha protein; HLA-DRB1-restricted epitope S1; HLA-DRB1-restricted epitope S2; HLA-DRB1-restricted epitope S3; HLA-DRB1-restricted epitope S4; HMWCK; intermediate filament protein; intermediate filament protein K16; intermediate filament protein; K7; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K2e; K2P; K3; K3 keratin; K4; K5; K6A; K7; K76; K77; K8; KERA; keratin 1 (epidermolytic hyperkeratosis); keratin 1, type II; keratin 10 (epidermolytic hyperkeratosis); keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris); keratin 10, type I; keratin 13; keratin 13, type I; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 15; keratin 15, type I; keratin 16 (focal non-epidermolytic palmoplantar keratoderma); keratin 16 homolog; keratin 16, type I; keratin 17, type I; keratin 18, type I; keratin 19; keratin 19, type I; Keratin 1B; keratin 2 epidermis; keratin 2, type II; keratin 2A (epidermal ichthyosis bullosa of Siemens); keratin 2p; keratin 3, type II; keratin 4, type II; keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6 alpha; keratin 6A, , type II; keratin 6A, type II; keratin 7, type II; keratin 76, type II; keratin 77, type II; keratin 8, type II; keratin 86; keratin complex 1, acidic, gene 10; keratin complex 1, acidic, gene 13; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 15; keratin complex 1, acidic, gene 16; keratin complex 1, acidic, gene 17; keratin complex 1, acidic, gene 18; keratin complex 1, acidic, gene 19; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 17; keratin complex 2, basic, gene 39; keratin complex 2, basic, gene 4; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin complex 2, basic, gene 7; keratin complex 2, basic, gene 8; keratin complex 2, gene 17; keratin complex 2, gene 6a; Keratin D; keratin intermediate filament 16a; keratin intermediate filament 16b; keratin IV; keratin K3; keratin K5; keratin type II; Keratin type II cytoskeletal 5; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 13; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 15; Keratin, type I cytoskeletal 16; Keratin, type I cytoskeletal 17; Keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 59 kDa; keratin, type I, 40-kd; Keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 1b; Keratin, type II cytoskeletal 2 epidermal; Keratin, type II cytoskeletal 2 oral; Keratin, type II cytoskeletal 3; Keratin, type II cytoskeletal 4; Keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 60 kDa, component III; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 7; Keratin, type II cytoskeletal 8; Keratin, type II cytoskeletal cochleal; Keratin-1; Keratin-10; Keratin-13; Keratin-14; Keratin-15; keratin-15, basic; keratin-15, beta; Keratin-16; Keratin-17; Keratin-18; Keratin-19; Keratin-2 epidermis; Keratin-2e; Keratin-3; Keratin-4; Keratin-5; Keratin-6-alpha; Keratin-6A; Keratin-7; Keratin-76; Keratin-77; Keratin-8; krt1 {ECO:0000250|UniProtKB:P04264}; krt10 {ECO:0000250|UniProtKB:P13645}; krt13 {ECO:0000250|UniProtKB:P13646}; krt15 {ECO:0000250|UniProtKB:P19012}; krt17 {ECO:0000250|UniProtKB:Q04695}; krt18 {ECO:0000250|UniProtKB:P05783}; KRT1B; krt2; krt2 {ECO:0000250|UniProtKB:P35908}; krt4 {ECO:0000250|UniProtKB:P19013}; KRT5; krt7; krt7 {ECO:0000250|UniProtKB:P08729}; krt76; masticatory epithelia keratin 2p; mK6-alpha; ORF; otokeratin; Pan CK; pan Cytokeratin; pan keratin; pankeratin; PIG46; Sarcolectin; suprabasal cytokeratin 10; tuftelin interacting protein 8; type I alpha-keratin 14; type I alpha-keratin 15; type I cytoskeletal 15; Type I keratin Ka10; Type I keratin Ka13; Type I keratin Ka14; Type I keratin Ka15; type I keratin KA16; Type I keratin Ka17; Type I keratin Ka19; type II alpha-keratin IIA; type II alpha-keratin IIC; type II cytokeratin A (no.8); type II cytoskeletal 1b; type II cytoskeletal cochleal; type II keratin Kb1; type II keratin Kb2; type II keratin Kb39; type II keratin Kb4; type II keratin Kb7; type II keratin Kb9; type II keratin subunit protein; type II mesothelial keratin K7; type-II intermediate filament protein; Type-II keratin Kb1; Type-II keratin Kb2; Type-II keratin Kb3; Type-II Keratin Kb39; Type-II keratin Kb4; Type-II keratin Kb5; Type-II keratin Kb6; Type-II keratin Kb7; Type-II keratin Kb8; Type-II keratin Kb9; unnamed protein product
Gene Aliases: 2310001L23Rik; 2310016L08Rik; 3300001P10Rik; 39.1; 4732484G22Rik; AA960620; AEI2; AI324768; AI528832; AI626930; AI663979; AL022697; AU019895; AW108092; AW146334; BB005427; BCIE; BIE; CARD2; CK-10; CK-14; CK-17; CK-18; CK-2e; CK-3; CK-4; CK-6C; CK-6E; CK-8; CK1; CK10; CK13; CK14; CK15; CK16; CK18; CK19; CK3; CK4; CK5; CK6A; CK6C; CK6D; CK7; CK8; CYK18; CYK4; CYK8; CYKER; D130054E02Rik; D15Wsu77e; DDD; DDD1; EBS1; EBS1A; EBS1B; EBS1C; EBS1D; EBS2; EBS2A; EBS2B; EBS2C; EBS2D; EBS2E; EBS2F; EBS3; EBS4; EHK; EHK1; EHK2; EHK2A; EHK2B; EndoA; EndoC; EPPK; FNEPPK; GK-19; HUMCYT2A; IHL; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K1C1; K1CO; K1CP; K1CS; K1emb; K2C7; K2C8; K2E; K3; K4; K5; K6A; K6C; K6D; K7; K8; Ka10; Ka13; Ka14; Ka15; Ka16; Ka17; Ka19; Kb1; Kb2; Kb39; Kb4; Kb7; Kb9; KER1; KER10; Ker2; keratin; keratin-19; Kerd; KERIA; KERIB; KO; KPP; Krt-1.10; Krt-1.13; Krt-1.14; Krt-1.19; Krt-2.1; Krt-2.4; Krt-2.8; KRT1; Krt1-10; Krt1-13; Krt1-14; Krt1-15; Krt1-16; Krt1-17; Krt1-18; Krt1-19; KRT10; KRT13; KRT14; KRT15; KRT16; KRT16A; KRT17; KRT18; KRT19; KRT1A; KRT1B; KRT2; Krt2-1; Krt2-17; Krt2-2; Krt2-4; Krt2-5; Krt2-6; Krt2-6a; Krt2-6c; Krt2-7; KRT2-8; Krt239; KRT2A; KRT2B; KRT2E; KRT2P; KRT3; KRT4; KRT5; KRT5A; Krt6; KRT6A; KRT6C; KRT6D; KRT7; KRT76; KRT77; KRT8; Krt86; KRTA; KRTB; KRTE; MECD2; mK1b; mK6[a]; MK6a; NEPPK; NFJ; PC; PC1; PC2; PC3; PCHC1; PIG46; Sak57; SCL; Tfip8; WSN1; WSN2
UniProt ID: (Dog) Q6EIY9, (Human) P04264, (Bovine) P06394, (Dog) Q6EIZ0, (Human) P13645, (Human) P13646, (Human) P02533, (Chicken) Q6PVZ1, (Human) P19012, (Human) P08779, (Human) Q04695, (Bovine) A1L595, (Dog) A0A8I3PJ84, (Human) P05783, (Bovine) P08728, (Human) P08727, (Human) P35908, (Chicken) O93256, (Rabbit) Q29426, (Human) P12035, (Human) P19013, (Human) P13647, (Bovine) Q5XQN5, (Human) P02538, (Bovine) Q29S21, (Human) P08729, (Chicken) O93532, (Human) Q01546, (Human) Q7Z794, (Bovine) P05786, (Human) P05787, (Mouse) P04104, (Rat) Q6IMF3, (Mouse) P02535, (Rat) Q6IFW6, (Mouse) P08730, (Rat) Q6IFV4, (Mouse) Q61781, (Rat) Q6IFV1, (Mouse) Q61414, (Rat) Q6IFV3, (Mouse) Q9Z2K1, (Mouse) Q9QWL7, (Rat) Q6IFU8, (Mouse) P05784, (Rat) Q5BJY9, (Mouse) P19001, (Rat) Q63279, (Mouse) Q3TTY5, (Rat) Q6IG02, (Rat) Q6IG00, (Mouse) P07744, (Rat) Q6P6Q2, (Mouse) Q922U2, (Mouse) P50446, (Rat) Q6IG12, (Mouse) Q9DCV7, (Mouse) Q3UV17, (Mouse) Q6IFZ6, (Rat) Q6IG01, (Rat) Q10758, (Mouse) P11679
Entrez Gene ID: (Dog) 444857, (Human) 3848, (Rabbit) 100353415, (Bovine) 281888, (Rabbit) 100009029, (Chicken) 771977, (Dog) 491006, (Human) 3858, (Dog) 490983, (Human) 3860, (Chicken) 408040, (Dog) 100685323, (Bovine) 404111, (Human) 3861, (Chicken) 408039, (Bovine) 507464, (Human) 3866, (Rabbit) 100341120, (Dog) 100685404, (Dog) 490978, (Rabbit) 100341376, (Human) 3868, (Dog) 490977, (Human) 3872, (Bovine) 281889, (Rabbit) 100344942, (Chicken) 100858439, (Bovine) 506480, (Dog) 477601, (Chicken) 101749333, (Human) 3875, (Rabbit) 100354174, (Bovine) 514812, (Dog) 100685481, (Human) 3880, (Rabbit) 100353162, (Dog) 444850, (Human) 3849, (Chicken) 395861, (Dog) 100683401, (Bovine) 407188, (Rabbit) 100353668, (Human) 3850, (Bovine) 527819, (Dog) 100682832, (Human) 3851, (Rabbit) 100348388, (Chicken) 407779, (Human) 3852, (Bovine) 281268, (Rabbit) 100352658, (Dog) 100687760, (Human) 3853, (Chicken) 408041, (Dog) 486523, (Bovine) 614456, (Dog) 477602, (Bovine) 535697, (Human) 3855, (Chicken) 395772, (Rabbit) 100345579, (Dog) 486518, (Bovine) 407189, (Human) 51350, (Rabbit) 103348273, (Dog) 100683333, (Human) 374454, (Rabbit) 100348891, (Bovine) 281269, (Dog) 486513, (Chicken) 426896, (Human) 3856, (Mouse) 16678, (Rat) 300250, (Mouse) 16661, (Rat) 450225, (Mouse) 16663, (Rat) 287699, (Mouse) 16664, (Rat) 287701, (Mouse) 16665, (Rat) 287700, (Rat) 303530, (Mouse) 16666, (Mouse) 16667, (Rat) 287702, (Mouse) 16668, (Rat) 294853, (Mouse) 16669, (Rat) 360626, (Mouse) 16681, (Rat) 406228, (Rat) 315323, (Mouse) 16682, (Rat) 369017, (Mouse) 110308, (Mouse) 16687, (Rat) 300242, (Mouse) 110310, (Rat) 407757, (Mouse) 77055, (Mouse) 406220, (Rat) 406226, (Rat) 25626, (Mouse) 16691, (Rabbit) 100344183
protein heterodimerization activity
protein binding
carbohydrate binding
structural constituent of epidermis
signaling receptor activity
structural molecule activity
structural constituent of cytoskeleton
keratin filament binding
scaffold protein binding
RNA binding
cadherin binding involved in cell-cell adhesion
structural constituent of muscle
macromolecular complex binding
cytoskeletal protein binding
molecular_function
MHC class II receptor activity
MHC class II protein binding
poly(A) RNA binding
protein complex binding
protein heterotetramerization
cytoskeleton organization
Notch signaling pathway
response to estrogen
sarcomere organization
cell differentiation involved in embryonic placenta development
positive regulation of epidermis development
aging
epithelial cell differentiation
hair cycle
intermediate filament bundle assembly
morphogenesis of an epithelium
positive regulation of cell proliferation
cell differentiation
keratinization
killing of cells of other organism
wound healing
intermediate filament organization
defense response to Gram-positive bacterium
antimicrobial humoral immune response mediated by antimicrobial peptide
negative regulation of entry of bacterium into host cell
biological_process
intermediate filament-based process
positive regulation of cell growth
hair follicle morphogenesis
positive regulation of translation
positive regulation of hair follicle development
cellular response to calcium ion
inflammatory response
keratinocyte differentiation
negative regulation of cell migration
innate immune response
intermediate filament cytoskeleton organization
keratinocyte migration
establishment of skin barrier
negative regulation of epithelial cell proliferation
complement activation, lectin pathway
negative regulation of inflammatory response
tumor necrosis factor-mediated signaling pathway
response to hydrostatic pressure
response to other organism
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
epidermis development
Wnt signaling pathway
response to mechanical stimulus
regulation of cell migration
regulation of protein localization
intermediate filament polymerization
response to oxidative stress
peptide cross-linking
fibrinolysis
regulation of angiogenesis
signal transduction
regulation of translation in response to stress
response to zinc ion
response to ionizing radiation
retina homeostasis
Golgi to plasma membrane CFTR protein transport
negative regulation of apoptotic process
response to radiation
stem cell differentiation
anatomical structure morphogenesis
Golgi to plasma membrane protein transport
cell-cell adhesion
mitophagy in response to mitochondrial depolarization
tongue morphogenesis
cellular response to retinoic acid
embryo development
sebaceous gland development
keratinocyte activation
keratinocyte proliferation
immune system process
cell morphogenesis involved in differentiation
multicellular organism development
pigmentation
keratinocyte development
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