Immunogen sequence: CREAACVWCN GEEYRGAVDR TESGRECQRW DLQHPHQHPF EPGKFLDQGL DDNYCRNPDG SERPWCYTTD PQIEREFCDL PRCGSEAQPR QEATTVSCFR GKGEGYRGTA NTTTAGVPCQ RWDAQIPHQH RFTPEKYACK DLRENFCRNP DGSEAPWCFT LRPGMRAAFC YQIRRCTDDV RPQDCYHGAG EQYRGTVSKT RKGVQCQRWS AETPHKPQFT FTSEPHAQLE ENFCRNPDGD SHGPWCYTMD PRTPFDYCAL RRCADDQPPS ILDPPDQVQF EKCGKRVDRL DQRRSKLRVV G; Positive Samples: Mouse kidney, Rat kidney
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation By similarity.
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Protein Aliases: D8h3f15s2; E2F transcription factor 2; Hepatocyte growth factor-like protein; Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain; hepatocyte growth factor-like protein homolog; macrophage stimulating 1 (hepatocyte growth factor-like); Macrophage stimulatory protein; Macrophage-stimulating protein; MSP
Gene Aliases: D3F15S2; D3F15S2h; D9H3F15S2; DNF15S2; DNF15S2h; E2F2; HGFL; MSP; MST1; NF15S2
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule