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MSR1 Polyclonal Antibody
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FIGURE: 1 / 1
MSR1 Antibody (BS-24362R) in WB
Lane 1:Mouse Spleen tissue lysates; Lane 2: Mouse Lung tissue lysates; Lane 3: Mouse Liver tissue lysates; Lane 4: Mouse Placenta tissue lysates ; Lane 5: Mouse Cerebrum tissue lysates; Lane 6: Mouse Raw264.7 cell lysates; Lane 7: Mouse NIH/3T3 cell lysates; Lane 8: Rat Liver tissue lysates; Lane 9: Rat Cerebrum tissue lysates probed with MSR1 Polyclonal Antibody, Unconjugated (bs-24362R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
Product Details
BS-24362R
Product Specifications
Species Reactivity
Rat,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from mouse MSR1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD204; Macrophage acetylated LDL receptor I and II; Macrophage scavenger receptor types I and II; Scavenger receptor type A; SR-A; SR-AI/II
Gene Aliases: MRS-A; MSR; MSR-A; Msr1; RGD1564316; Scara1; Scvr; SR-AI; SR-AII
UniProt ID: (Mouse) P30204
Entrez Gene ID: (Rat) 498638, (Mouse) 20288
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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