Immunogen sequence: GNSASNIVSP QEALPGRKEQ TPVAAKHHVN GNRTVEPFPE GTQMAVFGMG CFWGAERKFW VLKGVYSTQV GFAGGYTSNP TYKEVCSEKT GHAEVVRVVY QPEHMSFEEL LKVFWENHDP TQGMRQGNDH GTQYRSAIYP TSAKQMEAAL SSKENYQKVL SEHGFGPITT DIREGQTFYY AEDYHQQYLS KNPNGYCGLG GTGVSCPVGI KK; Positive Samples: Mouse kidney, Rat kidney; Cellular Location: Cytoplasm, Lipid-anchor, Membrane, Mitochondrion, Nucleus
Methionine sulfoxide reductase (MsrA) reduces methionine sulfoxide (MetO) residues in proteins and free MetO to Methionine (Met). The catalytic activity of MsrA is dependent of bound metal and cofactors but it requires reducing equivalents from either DTT or a thioredoxin-regenerating system. MsrA plays an essential role in protecting cells against oxidative damage. The substrates of MsrA include calmodulin, HIV protease and a 1-proteinase-inhibitor. Recent studies indicate that there is a connection between MsrA and Alzheimer's disease in mammals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cytosolic methionine-S-sulfoxide reductase; Mitochondrial peptide methionine sulfoxide reductase; peptide met (O) reductase; Peptide Met(O) reductase; peptide methionine sulfoxide reductase; Peptide-methionine (S)-S-oxide reductase; PMSR; Protein-methionine-S-oxide reductase
Gene Aliases: 2310045J23Rik; 6530413P12Rik; MSR-A; MSRA; PMSR