Immunogen sequence: MSAFNLLHLV TKSQPVALRA CGLPSGSCRD KKNCKVVFSQ QELRKRLTPL QYHVTQEKGT ESAFEGEYTH HKDPGIYKCV VCGTPLFKSE TKFDSGSGWP SFHDVINSEA ITFTDDFSYG MHRVETSCSQ CGAHLGHIFD DGPRPTGKRY CINSAALSFT PADSSGTAEG GSGVASPAQA DKAEL; Positive Samples: Mouse lung, Mouse testis, Mouse brain, Rat lung; Cellular Location: Endoplasmic reticulum, Mitochondrion
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: methionine sulfoxide reductase B3; Methionine-R-sulfoxide reductase B3; Methionine-R-sulfoxide reductase B3, mitochondrial; MsrB3
Gene Aliases: D430026P16Rik; DFNB74; I-8-23; MsrB2; MSRB3; UNQ1965/PRO4487