Immunogen sequence: EGHSDDESDS EGSDSESTSR ENNTHPEWSF TTVRKKPDPK KVQNGAEQDL VQTLSCLSMI ITPAFAELKQ QDENNASRNQ AIEELEKSIA VAEAACPGIT DKMVKKLIEK FQKCSADESP; Positive Samples: Rat thymus; Cellular Location: Cytoplasm, Cytoplasmic side, Golgi apparatus membrane, Peripheral membrane protein
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
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Protein Aliases: serine/threonine protein kinase MST4; serine/threonine-protein kinase MST4
Gene Aliases: Mask; Mst4; RGD1563568
Entrez Gene ID: (Rat) 317589