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Invitrogen
MSX1 Polyclonal Antibody
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FIGURE: 1 / 2
MSX1 Antibody (720172) in ICC/IF
For immunofluorescence analysis HeLa cells were fixed and permeabilized for detection of MSX1 using MSX1 Rabbit Polyclonal antibody (Product # 720172, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of endogenous MSX1 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). Panel c) represen... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
720172
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Protein corresponding to Human MSX1 (aa 1-303)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2-7.4, with 30% glycerol, 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Horse and Rabbit.
Target Information
MSX1 is a member of the muscle segment homeobox gene family. It functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. MSX1 may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in the gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeobox 7; homeobox protein Hox-7; msh homeo box 1; msh homeobox 1-like protein; msh homeobox homolog 1; unnamed protein product
Gene Aliases: ECTD3; HOX7; HYD1; STHAG1
UniProt ID: (Human) P28360
Entrez Gene ID: (Human) 4487
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
p53 binding
DNA binding
protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
epithelial to mesenchymal transition
cardiac conduction system development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
organ morphogenesis
mesenchymal cell proliferation
negative regulation of gene expression
negative regulation of cell growth
protein localization to nucleus
embryonic nail plate morphogenesis
odontogenesis of dentin-containing tooth
odontogenesis
regulation of odontogenesis
positive regulation of odontogenesis
positive regulation of DNA damage response, signal transduction by p53 class mediator
nose development
positive regulation of cell cycle
positive regulation of transcription from RNA polymerase II promoter
embryonic morphogenesis
inner ear development
protein stabilization
palate development
face morphogenesis
negative regulation of odontoblast differentiation
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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