HOX7 is a 297 amino acid novel member of homeodomain family of DNA binding domain family (meta HOX) that functions as a DNA-associated transcription factor. It has a helix-turn-helix and DNA binding domain. It plays an important role in inhibiting MYOD1 expression and is involved in epithelial-mesenchymal signaling in many organs, playing a role in limb-pattern formation. It acts as a potential repressor in cell cycle progression and as a RNA polymerase 2 transcription factor, involved in skeletal development. Northern blot analysis detects highest expression of HOX7 in heart along with other tissues like prostate and highly in dental mesenchyme during critical bud stage, placenta, etc.
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Protein Aliases: homeo box, msh-like 1; homeobox 7; Homeobox protein Hox-7; Homeobox protein MSX-1; homeobox, msh-like 1; Hox-7.1; HOX7; HYD1; msh homeo box 1; Msh homeobox 1-like protein; msh homeobox homolog 1; muscle-segment homeobox; STHAG1
Gene Aliases: AA675338; AI324650; ECTD3; Hox-7; HOX7; Hox7.1; HYD1; msh; MSX1; STHAG1