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Product Details
PA5-82202
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MSX2. Recombinant protein control fragment (Product #RP-100707).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2789363
Product Specific Information
Immunogen sequence: SSLPFSVEAL MSDKKPPKEA SPLPAESASA GATLRPLLLS GHGAREAHSP GPLVKPFETA SVKSENSEDG AAWMQEPGRY SPPPRHTSPT TCTLRKHKTN RKP
Target Information
Msx2 is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. This protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in the Msx2 gene are associated with parietal foramina 1 and craniosynostosis type 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homeobox protein Hox-8; Homeobox protein MSX-2; msh homeo box 2; msh homeobox homolog 2
Gene Aliases: CRS2; FPP; HOX8; MSH; MSX2; PFM; PFM1
UniProt ID: (Human) P35548
Entrez Gene ID: (Human) 4488
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription cofactor activity
protein binding
transcription factor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
chondrocyte development
osteoblast development
outflow tract septum morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
endochondral bone growth
transcription from RNA polymerase II promoter
negative regulation of cell proliferation
anterior/posterior pattern specification
signal transduction involved in regulation of gene expression
positive regulation of BMP signaling pathway
negative regulation of CREB transcription factor activity
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
wound healing, spreading of epidermal cells
embryonic nail plate morphogenesis
negative regulation of apoptotic process
negative regulation of fat cell differentiation
negative regulation of keratinocyte differentiation
positive regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
stem cell differentiation
positive regulation of catagen
bone trabecula formation
cranial suture morphogenesis
frontal suture morphogenesis
branching involved in mammary gland duct morphogenesis
BMP signaling pathway involved in heart development
enamel mineralization
cellular response to estradiol stimulus
activation of meiosis
negative regulation of transcription regulatory region DNA binding
positive regulation of mesenchymal cell apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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