Msx2 is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. This protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in the Msx2 gene are associated with parietal foramina 1 and craniosynostosis type 2.
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Protein Aliases: Homeobox protein Hox-8; homeobox protein Hox-8-1; Homeobox protein MSX-2; hox-8.1; msh homeo box 2; msh homeo box homolog 2; msh homeobox homolog 2
Gene Aliases: CRS2; FPP; HOX8; MSH; MSX2; PFM; PFM1
UniProt ID: (Human) P35548
Molecular Function: homeodomain transcription factor