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Invitrogen

MSX2 Polyclonal Antibody

View all (12) MSX2 antibodies

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MSX2 Polyclonal Antibody

Product Details

PA5-97984

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

ELISA (ELISA)

Assay-Dependent
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human Homeobox protein MSX-2 protein (50-120AA)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.03% ProClin 300

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2812598

Target Information

Msx2 is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. This protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in the Msx2 gene are associated with parietal foramina 1 and craniosynostosis type 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: homeobox protein; Homeobox protein Hox-8; homeobox protein Hox-8-1; Homeobox protein MSX-2; hox-8.1; msh homeo box 2; msh homeo box homolog 2; msh homeobox homolog 2

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Gene Aliases: CRS2; FPP; HOX8; MSH; MSX2; PFM; PFM1

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UniProt ID: (Human) P35548

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Entrez Gene ID: (Human) 4488, (Rat) 25483

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding protein binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, transcription factor binding transcription cofactor activity transcription factor binding transcription regulatory region DNA binding homeodomain transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter ossification osteoblast differentiation chondrocyte development osteoblast development outflow tract septum morphogenesis outflow tract morphogenesis cardiac conduction system development epithelial to mesenchymal transition involved in endocardial cushion formation endochondral bone growth regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter negative regulation of cell proliferation organ morphogenesis anterior/posterior pattern specification signal transduction involved in regulation of gene expression embryonic limb morphogenesis BMP signaling pathway positive regulation of BMP signaling pathway embryonic forelimb morphogenesis embryonic hindlimb morphogenesis wound healing, spreading of epidermal cells embryonic nail plate morphogenesis wound healing odontogenesis embryonic digit morphogenesis regulation of apoptotic process negative regulation of apoptotic process negative regulation of fat cell differentiation negative regulation of keratinocyte differentiation positive regulation of osteoblast differentiation negative regulation of transcription, DNA-templated embryonic morphogenesis stem cell differentiation cartilage development positive regulation of catagen bone trabecula formation bone morphogenesis cranial suture morphogenesis frontal suture morphogenesis branching involved in mammary gland duct morphogenesis mammary gland epithelium development cell surface receptor signaling pathway involved in heart development enamel mineralization cellular response to growth factor stimulus cellular response to estradiol stimulus activation of meiosis mesenchymal cell apoptotic process positive regulation of mesenchymal cell apoptotic process transcription from RNA polymerase II promoter negative regulation of CREB transcription factor activity positive regulation of apoptotic process BMP signaling pathway involved in heart development negative regulation of transcription regulatory region DNA binding
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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