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MT-ND2 Antibody (PA5-37185) in WB
Western blot analysis of MT-ND2 in Lane 1: LOVO whole cell lysate (30 µg), Lane 2: L02 whole cell lysate (30 µg), Lane 3: the Heart tissue lysate of mouse (40 µg), Lane 4: the Kidney tissue lysate of rat (40 µg), Lane 5: H9C2 whole cell lysate (40 µg), Lane 6: CT26 whole cell lysate (40 µg), Lane 7: SGC7901 whole cell lysate (40 µg). Samples were incubated with MT-ND2 polyclonal antibody (Product # PA5-37185) at a dilution of 1:1,000.
Product Details
PA5-37185
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to residues in human MT-ND2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2553948
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 39 kDa.
Purity is >95% by SDS-PAGE.
Target Information
MT-ND2: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in MT-ND2 are a cause of Leber hereditary optic neuropathy (LHON). LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Defects in MT-ND2 may be associated with susceptibility to Alzheimer disease mitochondrial (AD-MT).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: NADH dehydrogenase subunit 2; NADH-ubiquinone oxidoreductase chain 2
Gene Aliases: MT-ND2; MTND2; NADH2; ND2
UniProt ID: (Human) P03891, (Rat) P11662, (Mouse) P03893
Entrez Gene ID: (Human) 4536, (Rat) 26194, (Mouse) 17717
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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