Proteintech

MT1-MMP Polyclonal Antibody

MT1-MMP Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

MT1-MMP Antibody (14552-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using (Product # 14552-1-AP) (MT1-MMP antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Product Image Gallery

Product Details

14552-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 20 publications 20 publications

Immunohistochemistry (IHC)

Assay-dependent

View 5 publications 5 publications

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MT1-MMP Fusion Protein Ag5965 (1-350 aa encoded by BC064803)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSPAPRPSR CLLLPLLTLG TALASLGSAQ SSSFSPEAWL QQYGYLPPGD LRTHTQRSPQ SLSAAIAAMQ KFYGLQVTGK ADADTMKAMR RPRCGVPDKF GAEIKANVRR KRYAIQGLKW QHNEITFCIQ NYTPKVGEYA TYEAIRKAFR VWESATPLRF REVPYAYIRE GHEKQADIMI FFAEGFHGDS TPFDGEGGFL AHAYFPGPNI GGDTHFDSAE PWTVRNEDLN GNDIFLVAVH ELGHALGLEH SSDPSAIMAP FYQWMDTENF VLPDDDRRGI QQLYGGESGF PTKMPPQPRT TSRPSVPDKP KNPTYGPNIC DGNFDTVAML RGEMFVFKER WFWRVRNNQV M (1-350 aa encoded by BC064803)

Target Information

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

PLOD2 Is a Prognostic Marker in Glioblastoma That Modulates the Immune Microenvironment and Tumor Progression.

International journal of molecular sciences

Kreße N,Schröder H,Stein KP,Wilkens L,Mawrin C,Sandalcioglu IE,Dumitru CA

Fri May 27 00:00:00 EDT 2022

Decrease of circARID1A retards glioblastoma invasion by modulating miR-370-3p/ TGFBR2 pathway.

International journal of biological sciences

Li B,Chen J,Wu Y,Luo H,Ke Y

Mon Aug 22 00:00:00 EDT 2022

Heat Shock Proteins 70 Regulate Cell Motility and Invadopodia-Associated Proteins Expression in Oral Squamous Cell Carcinoma.

Frontiers in endocrinology

Ding LX,Zhang J,Yang SS,Wu J,Su T,Wang WM

Mon Aug 15 00:00:00 EDT 2022

Dual VEGF/PDGF knockdown suppresses vasculogenic mimicry formation in choroidal melanoma cells via the Wnt5a/β-catenin/AKT signaling pathway.

Acta histochemica

Yuan Y,Geng B,Xu X,Zhao H,Bai J,Dou Z,Jia S,Yu X,Luo W

Sat Jan 01 00:00:00 EST 2022

WISP2/CCN5 Suppresses Vasculogenic Mimicry through Inhibition of YAP/TAZ Signaling in Breast Cancer Cells.

Cancers

Ferrand N,Fert A,Morichon R,Radosevic-Robin N,Zaoui M,Sabbah M

Mon Mar 14 00:00:00 EDT 2022

LOXL1-AS1 communicating with TIAR modulates vasculogenic mimicry in glioma via regulation of the miR-374b-5p/MMP14 axis.

Journal of cellular and molecular medicine

Yi B,Li H,Cai H,Lou X,Yu M,Li Z

Sat Jan 01 00:00:00 EST 2022

METTL3-mediated m⁶A modification of TIMP2 mRNA promotes podocyte injury in diabetic nephropathy.

Molecular therapy : the journal of the American Society of Gene Therapy

Jiang L,Liu X,Hu X,Gao L,Zeng H,Wang X,Huang Y,Zhu W,Wang J,Wen J,Meng X,Wu Y

Wed Apr 06 00:00:00 EDT 2022

miR-520d-3p/MIG-7 axis regulates vasculogenic mimicry formation and metastasis in osteosarcoma.

Neoplasma

Yao N,Zhou J,Song J,Jiang Y,Zhang J

Fri Jul 01 00:00:00 EDT 2022

ACADL Functions as a Tumor Suppressor in Hepatocellular Carcinoma Metastasis by Inhibiting Matrix Metalloproteinase 14.

Frontiers in oncology

Guo D,Zhang X,Cui H,Yu D,Zhang H,Shi X,Pang C,Li J,Guo W,Zhang S

Sat Feb 19 00:00:00 EST 2022

ACADL Functions as a Tumor Suppressor in Hepatocellular Carcinoma Metastasis by Inhibiting Matrix Metalloproteinase 14.

Frontiers in oncology

Guo D,Zhang X,Cui H,Yu D,Zhang H,Shi X,Pang C,Li J,Guo W,Zhang S

Sat Feb 19 00:00:00 EST 2022

LncRNA H19-Derived miR-675-5p Accelerates the Invasion of Extravillous Trophoblast Cells by Inhibiting GATA2 and Subsequently Activating Matrix Metalloproteinases.

International journal of molecular sciences

Ogoyama M,Ohkuchi A,Takahashi H,Zhao D,Matsubara S,Takizawa T

Wed Jan 27 00:00:00 EST 2021

Urinary peptidomics reveals proteases involved in idiopathic membranous nephropathy.

BMC genomics

Lin B,Liu J,Zhang Y,Wu Y,Chen S,Bai Y,Liu Q,Qin X

Wed Nov 24 00:00:00 EST 2021

GABARAP suppresses EMT and breast cancer progression via the AKT/mTOR signaling pathway.

Aging

Liu Y,Wang D,Lei M,Gao J,Cui Y,Jin X,Yu Q,Jiang Y,Guo Y,Liu Y,Cai L,Chen X

Thu Feb 11 00:00:00 EST 2021

Transition of podosomes into zipper-like structures in macrophage-derived multinucleated giant cells.

Molecular biology of the cell

Balabiyev A,Podolnikova NP,Mursalimov A,Lowry D,Newbern JM,Roberson RW,Ugarova TP

Sat Aug 15 00:00:00 EDT 2020

SPOCK2 Affects the Biological Behavior of Endometrial Cancer Cells by Regulation of MT1-MMP and MMP2.

Reproductive sciences (Thousand Oaks, Calif.)

Ren F,Wang D,Wang Y,Chen P,Guo C

Wed Jul 01 00:00:00 EDT 2020

MT1-MMP downregulation via the PI3K/Akt signaling pathway is required for the mechanical stretching-inhibited invasion of bone-marrow-derived mesenchymal stem cells.

Journal of cellular physiology

Fu X,Halim A,Tian B,Luo Q,Song G

Thu Aug 01 00:00:00 EDT 2019

MT1-MMP downregulation via the PI3K/Akt signaling pathway is required for the mechanical stretching-inhibited invasion of bone-marrow-derived mesenchymal stem cells.

Journal of cellular physiology

Fu X,Halim A,Tian B,Luo Q,Song G

Thu Aug 01 00:00:00 EDT 2019

VEGF Induce Vasculogenic Mimicry of Choroidal Melanoma through the PI3k Signal Pathway.

BioMed research international

Xu X,Zong Y,Gao Y,Sun X,Zhao H,Luo W,Jia S

Thu Jan 02 00:00:00 EST 2020

SPOCK2 Affects the Biological Behavior of Endometrial Cancer Cells by Regulation of MT1-MMP and MMP2.

Reproductive sciences (Thousand Oaks, Calif.)

Ren F,Wang D,Wang Y,Chen P,Guo C

Mon Mar 04 00:00:00 EST 2019

NAB 2-Expressing Cancer-Associated Fibroblast Promotes HNSCC Progression.

Cancers

Choi SY,Oh SY,Kang SH,Kang SM,Kim J,Lee HJ,Kwon TG,Kim JW,Hong SH

Tue Mar 19 00:00:00 EDT 2019

Upregulation of SPOCK2 inhibits the invasion and migration of prostate cancer cells by regulating the MT1-MMP/MMP2 pathway.

PeerJ

Liu G,Ren F,Song Y

Sat Apr 09 00:00:00 EDT 2022

Knockdown of USF1 Inhibits the Vasculogenic Mimicry of Glioma Cells via Stimulating SNHG16/miR-212-3p and linc00667/miR-429 Axis.

Molecular therapy. Nucleic acids

Wang D,Zheng J,Liu X,Xue Y,Liu L,Ma J,He Q,Li Z,Cai H,Liu Y

Fri Mar 01 00:00:00 EST 2019

Long Non-coding RNA LINC00339 Stimulates Glioma Vasculogenic Mimicry Formation by Regulating the miR-539-5p/TWIST1/MMPs Axis.

Molecular therapy. Nucleic acids

Guo J,Cai H,Liu X,Zheng J,Liu Y,Gong W,Chen J,Xi Z,Xue Y

Fri Mar 02 00:00:00 EST 2018

Long Non-coding RNA LINC00339 Stimulates Glioma Vasculogenic Mimicry Formation by Regulating the miR-539-5p/TWIST1/MMPs Axis.

Molecular therapy. Nucleic acids

Guo J,Cai H,Liu X,Zheng J,Liu Y,Gong W,Chen J,Xi Z,Xue Y

Fri Mar 02 00:00:00 EST 2018

MiR-122 inhibits epithelial mesenchymal transition by regulating P4HA1 in ovarian cancer cells.

Cell biology international

Duan Y,Dong Y,Dang R,Hu Z,Yang Y,Hu Y,Cheng J

Thu Nov 01 00:00:00 EDT 2018

MiR-122 inhibits epithelial mesenchymal transition by regulating P4HA1 in ovarian cancer cells.

Cell biology international

Duan Y,Dong Y,Dang R,Hu Z,Yang Y,Hu Y,Cheng J

Thu Nov 01 00:00:00 EDT 2018

Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor κB-Matrix Metalloproteinase Signaling.

Chemical research in toxicology

Wang Y,Wang Y,Liu Z,Dong W,Yang B,Xia X,Song E,Song Y

Mon Sep 17 00:00:00 EDT 2018

Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor κB-Matrix Metalloproteinase Signaling.

Chemical research in toxicology

Wang Y,Wang Y,Liu Z,Dong W,Yang B,Xia X,Song E,Song Y

Mon Sep 17 00:00:00 EDT 2018

Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor κB-Matrix Metalloproteinase Signaling.

Chemical research in toxicology

Wang Y,Wang Y,Liu Z,Dong W,Yang B,Xia X,Song E,Song Y

Mon Sep 17 00:00:00 EDT 2018

MMP-14 aggravates onset of severe preeclampsia by mediating soluble endoglin release.

European review for medical and pharmacological sciences

Zhang XH,Zhang HY,Lu S,Jiang LL,Wu J,Yang YL,Zhang SA

Thu Mar 01 00:00:00 EST 2018

MMP-14 aggravates onset of severe preeclampsia by mediating soluble endoglin release.

European review for medical and pharmacological sciences

Zhang XH,Zhang HY,Lu S,Jiang LL,Wu J,Yang YL,Zhang SA

Thu Mar 01 00:00:00 EST 2018

MMP-14 aggravates onset of severe preeclampsia by mediating soluble endoglin release.

European review for medical and pharmacological sciences

Zhang XH,Zhang HY,Lu S,Jiang LL,Wu J,Yang YL,Zhang SA

Thu Mar 01 00:00:00 EST 2018

MMP-14 aggravates onset of severe preeclampsia by mediating soluble endoglin release.

European review for medical and pharmacological sciences

Zhang XH,Zhang HY,Lu S,Jiang LL,Wu J,Yang YL,Zhang SA

Thu Mar 01 00:00:00 EST 2018

Hypoxia Activates Src and Promotes Endocytosis Which Decreases MMP-2 Activity and Aggravates Renal Interstitial Fibrosis.

International journal of molecular sciences

Cheng Z,Liu L,Wang Z,Cai Y,Xu Q,Chen P

Thu Feb 15 00:00:00 EST 2018

Hypoxia Activates Src and Promotes Endocytosis Which Decreases MMP-2 Activity and Aggravates Renal Interstitial Fibrosis.

International journal of molecular sciences

Cheng Z,Liu L,Wang Z,Cai Y,Xu Q,Chen P

Thu Feb 15 00:00:00 EST 2018

Long non-coding RNA MALAT1 promotes gastric cancer tumorigenicity and metastasis by regulating vasculogenic mimicry and angiogenesis.

Cancer letters

Li Y,Wu Z,Yuan J,Sun L,Lin L,Huang N,Bin J,Liao Y,Liao W

Thu Jun 01 00:00:00 EDT 2017

Long non-coding RNA MALAT1 promotes gastric cancer tumorigenicity and metastasis by regulating vasculogenic mimicry and angiogenesis.

Cancer letters

Li Y,Wu Z,Yuan J,Sun L,Lin L,Huang N,Bin J,Liao Y,Liao W

Thu Jun 01 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: EC 3.4.24.80; matrix metallo protease; matrix metallopeptidase 14 (membrane-inserted); matrix metalloproteinase 14 (membrane-inserted); matrix metalloproteinase 14 membrane-inserted; matrix metalloproteinase 14, membrane-inserted; Matrix metalloproteinase-14; membrane type 1 metalloprotease; membrane type 1-matrix metalloproteinase; Membrane type 1-MMP; Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase; MMP; MMP-14; MMP-X MT-MMP; MMP-X1; MMPs; MT-MMP; MT-MMP 1; MT-MMP MT1-MMP; MT1-MMP; MT1MMP; MTMMP1; type 1 matrix metalloprotease 14

View more View less

Gene Aliases: AI325305; MMP-14; MMP-X1; MMP14; MT-MMP; MT-MMP 1; MT-MMP-1; MT1-MMP; MT1MMP; Mtmmp; MTMMP1; sabe; WNCHRS

View more View less

UniProt ID: (Human) P50281, (Mouse) P53690, (Rat) Q10739

View more View less

Entrez Gene ID: (Human) 4323, (Mouse) 17387, (Rat) 81707

View more View less

Function(s)

metalloendopeptidase activity serine-type endopeptidase activity integrin binding calcium ion binding protein binding zinc ion binding peptidase activator activity transcription factor activity, sequence-specific DNA binding peptidase activity metallopeptidase activity hydrolase activity metal ion binding metalloprotease

Process(es)

angiogenesis ovarian follicle development response to hypoxia endothelial cell proliferation endochondral ossification proteolysis response to oxidative stress male gonad development response to mechanical stimulus response to hormone positive regulation of myotube differentiation positive regulation of peptidase activity response to organic cyclic compound extracellular matrix disassembly positive regulation of cell growth lung development positive regulation of cell migration collagen catabolic process zymogen activation endodermal cell differentiation chondrocyte proliferation astrocyte cell migration response to estrogen positive regulation of B cell differentiation negative regulation of Notch signaling pathway embryonic cranial skeleton morphogenesis branching morphogenesis of an epithelial tube tissue remodeling negative regulation of focal adhesion assembly craniofacial suture morphogenesis ossification regulation of transcription, DNA-templated cell migration bone development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

MT1-MMP Polyclonal Antibody

MT1-MMP Antibody (14552-1-AP) in ICC/IF

Product Details

14552-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!