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Proteintech
MTA1 Polyclonal Antibody
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Product Details
30545-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MTA1 fusion protein Ag30994
Conjugate
Form
Liquid
Concentration
0.75 mg/mL
Amount
112.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: TARLPEASQS PLVLKQAVRK PLEAVLRYLE THPRPPKPDP VKSVSSVLSS LTPAKVAPVI NNGSPTILGK RSYEQHNGVD GNMKKRLLMP SRGLANHGQA RHMGPSRNLL LNGKSYPTKV RLIRGGSLPP VKRRRMNWID APDDVFYMAT EETRKIRKLL SSSETK
Target Information
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: metastasis associated gene 1 protein; metastasis-associated gene; Metastasis-associated protein MTA1; MTA1 splice variant; unnamed protein product
Gene Aliases: MTA1
UniProt ID: (Human) Q13330, (Mouse) Q8K4B0
Entrez Gene ID: (Human) 9112, (Mouse) 116870
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
chromatin binding
transcription coactivator activity
transcription corepressor activity
protein binding
zinc ion binding
histone deacetylase binding
sequence-specific DNA binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
core promoter sequence-specific DNA binding
core promoter binding
RNA polymerase II repressing transcription factor binding
transcription factor activity, sequence-specific DNA binding
enzyme binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
double-strand break repair
chromatin remodeling
regulation of transcription, DNA-templated
signal transduction
response to ionizing radiation
circadian regulation of gene expression
regulation of cell fate specification
entrainment of circadian clock by photoperiod
proteasome-mediated ubiquitin-dependent protein catabolic process
locomotor rhythm
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
rhythmic process
positive regulation of protein autoubiquitination
regulation of stem cell differentiation
transcription, DNA-templated
response to lipopolysaccharide
secretory granule organization
regulation of gene expression, epigenetic
regulation of inflammatory response
regulation of nucleic acid-templated transcription
negative regulation of nucleic acid-templated transcription
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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