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Active Motif
MTA2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
39359
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This MTA2 antibody was raised against a peptide corresponding to the C-terminus of human MTA2.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum with 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686F2281; metastais-associated gene family, member 2; metastasis -associated gene 1-like 1; metastasis associated gene family, member 2; metastasis-associated 1-like 1; metastasis-associated protein 2; MTA1-L1 protein; p53 target protein in deacetylase complex; similar to metastasis associated protein MTA1; unnamed protein product
Gene Aliases: Mata1l1; mmta2; MTA1L1; PID
UniProt ID: (Human) O94776, (Mouse) Q9R190
Entrez Gene ID: (Human) 9219, (Mouse) 23942
chromatin binding
transcription cofactor activity
transcription coactivator activity
transcription corepressor activity
histone deacetylase activity
protein binding
nucleosomal DNA binding
histone deacetylase binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
DNA-binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
chromatin remodeling
regulation of transcription, DNA-templated
regulation of fibroblast migration
regulation of cell fate specification
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
chromosome organization
genetic imprinting
regulation of stem cell differentiation
chromatin organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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