Product References
JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy.
Molecular cancer research : MCR
Rosario SR,Jacobi JJ,Long MD,Affronti HC,Rowsam AM,Smiraglia DJ
Tue Jan 03 00:00:00 UTC 2023
Integrative Clinical and Genomic Characterization of MTAP-deficient Metastatic Urothelial Cancer.
European urology oncology
Alhalabi O,Zhu Y,Hamza A,Qiao W,Lin Y,Wang RM,Shah AY,Campbell MT,Holla V,Kamat A,Wang WL,Wang J,Chen J,Meng J,Zhang M,Bondaruk J,Titus M,Genovese G,Czerniak BA,Shaw KR,Meric-Bernstam F,Guo CC,Logothetis CJ,Siefker-Radtke A,Msaouel P,Wang L,Liu J,Gao J
Sat Apr 01 00:00:00 UTC 2023
MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers.
Nature communications
Alhalabi O,Chen J,Zhang Y,Lu Y,Wang Q,Ramachandran S,Tidwell RS,Han G,Yan X,Meng J,Wang R,Hoang AG,Wang WL,Song J,Lopez L,Andreev-Drakhlin A,Siefker-Radtke A,Zhang X,Benedict WF,Shah AY,Wang J,Msaouel P,Zhang M,Guo CC,Czerniak B,Behrens C,Soto L,Papadimitrakopoulou V,Lewis J,Rinsurongkawong W,Rinsurongkawong V,Lee J,Roth J,Swisher S,Wistuba I,Heymach J,Wang J,Campbell MT,Efstathiou E,Titus M,Logothetis CJ,Ho TH,Zhang J,Wang L,Gao J
Mon Apr 04 00:00:00 UTC 2022
MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers.
Nature communications
Alhalabi O,Chen J,Zhang Y,Lu Y,Wang Q,Ramachandran S,Tidwell RS,Han G,Yan X,Meng J,Wang R,Hoang AG,Wang WL,Song J,Lopez L,Andreev-Drakhlin A,Siefker-Radtke A,Zhang X,Benedict WF,Shah AY,Wang J,Msaouel P,Zhang M,Guo CC,Czerniak B,Behrens C,Soto L,Papadimitrakopoulou V,Lewis J,Rinsurongkawong W,Rinsurongkawong V,Lee J,Roth J,Swisher S,Wistuba I,Heymach J,Wang J,Campbell MT,Efstathiou E,Titus M,Logothetis CJ,Ho TH,Zhang J,Wang L,Gao J
Mon Apr 04 00:00:00 UTC 2022
Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy.
Nature communications
Affronti HC,Rowsam AM,Pellerite AJ,Rosario SR,Long MD,Jacobi JJ,Bianchi-Smiraglia A,Boerlin CS,Gillard BM,Karasik E,Foster BA,Moser M,Wilton JH,Attwood K,Nikiforov MA,Azabdaftari G,Pili R,Phillips JG,Casero RA,Smiraglia DJ
Tue Jan 07 00:00:00 UTC 2020
Polyamine pathway activity promotes cysteine essentiality in cancer cells.
Nature metabolism
Zhang T,Bauer C,Newman AC,Uribe AH,Athineos D,Blyth K,Maddocks ODK
Thu Oct 01 00:00:00 UTC 2020
Loss of 5'-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness.
Cells
Menezes WP,Silva VAO,Gomes INF,Rosa MN,Spina MLC,Carloni AC,Alves ALV,Melendez M,Almeida GC,Silva LSD,Clara C,da Cunha IW,Hajj GNM,Jones C,Bidinotto LT,Reis RM
Thu Feb 20 00:00:00 UTC 2020
Loss of 5'-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness.
Cells
Menezes WP,Silva VAO,Gomes INF,Rosa MN,Spina MLC,Carloni AC,Alves ALV,Melendez M,Almeida GC,Silva LSD,Clara C,da Cunha IW,Hajj GNM,Jones C,Bidinotto LT,Reis RM
Thu Feb 20 00:00:00 UTC 2020
HSP60-regulated Mitochondrial Proteostasis and Protein Translation Promote Tumor Growth of Ovarian Cancer.
Scientific reports
Guo J,Li X,Zhang W,Chen Y,Zhu S,Chen L,Xu R,Lv Y,Wu D,Guo M,Liu X,Lu W,Deng H
Mon Sep 02 00:00:00 UTC 2019
Abstracts from USCAP 2019: Pulmonary Pathology (1803-1896).
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
No authors listed
Fri Mar 01 00:00:00 UTC 2019
SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth.
The Journal of clinical investigation
Tamiya H,Kim H,Klymenko O,Kim H,Feng Y,Zhang T,Han JY,Murao A,Snipas SJ,Jilaveanu L,Brown K,Kluger H,Zhang H,Iwai K,Ronai ZA
Tue Jan 02 00:00:00 UTC 2018
SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth.
The Journal of clinical investigation
Tamiya H,Kim H,Klymenko O,Kim H,Feng Y,Zhang T,Han JY,Murao A,Snipas SJ,Jilaveanu L,Brown K,Kluger H,Zhang H,Iwai K,Ronai ZA
Tue Jan 02 00:00:00 UTC 2018
Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors.
Biomarkers in medicine
Abrahao-Machado LF,Antunes B,Filippi RZ,Volc S,Boldrini E,Menezes WP,Reis RM,de Camargo OP
Mon Jan 01 00:00:00 UTC 2018
Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors.
Biomarkers in medicine
Abrahao-Machado LF,Antunes B,Filippi RZ,Volc S,Boldrini E,Menezes WP,Reis RM,de Camargo OP
Mon Jan 01 00:00:00 UTC 2018
USCAP 2018 Abstracts: Bone and Soft Tissue Pathology (45-120).
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
No authors listed
Thu Mar 01 00:00:00 UTC 2018
CDKN2A loss and PIK3CA mutation in myoepithelial-like metaplastic breast cancer.
The Journal of pathology
Bartels S,van Luttikhuizen JL,Christgen M,Mägel L,Luft A,Hänzelmann S,Lehmann U,Schlegelberger B,Leo F,Steinemann D,Kreipe H
Sun Jul 01 00:00:00 UTC 2018
Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model.
Oncotarget
Affronti HC,Long MD,Rosario SR,Gillard BM,Karasik E,Boerlin CS,Pellerite AJ,Foster BA,Attwood K,Pili R,Wilton JH,Campbell MJ,Smiraglia DJ
Tue Nov 28 00:00:00 UTC 2017
Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model.
Oncotarget
Affronti HC,Long MD,Rosario SR,Gillard BM,Karasik E,Boerlin CS,Pellerite AJ,Foster BA,Attwood K,Pili R,Wilton JH,Campbell MJ,Smiraglia DJ
Tue Nov 28 00:00:00 UTC 2017
The essential role of methylthioadenosine phosphorylase in prostate cancer.
Oncotarget
Bistulfi G,Affronti HC,Foster BA,Karasik E,Gillard B,Morrison C,Mohler J,Phillips JG,Smiraglia DJ
Tue Mar 22 00:00:00 UTC 2016
Suppressive effects of tumor cell-derived 5'-deoxy-5'-methylthioadenosine on human T cells.
Oncoimmunology
Henrich FC,Singer K,Poller K,Bernhardt L,Strobl CD,Limm K,Ritter AP,Gottfried E,Völkl S,Jacobs B,Peter K,Mougiakakos D,Dettmer K,Oefner PJ,Bosserhoff AK,Kreutz MP,Aigner M,Mackensen A
Mon Aug 01 00:00:00 UTC 2016
Suppressive effects of tumor cell-derived 5'-deoxy-5'-methylthioadenosine on human T cells.
Oncoimmunology
Henrich FC,Singer K,Poller K,Bernhardt L,Strobl CD,Limm K,Ritter AP,Gottfried E,Völkl S,Jacobs B,Peter K,Mougiakakos D,Dettmer K,Oefner PJ,Bosserhoff AK,Kreutz MP,Aigner M,Mackensen A
Mon Aug 01 00:00:00 UTC 2016
Expression of Methylthioadenosine Phosphorylase (MTAP) in Pilocytic Astrocytomas.
Pathobiology : journal of immunopathology, molecular and cellular biology
Becker AP,Scapulatempo-Neto C,Menezes WP,Clara C,Machado HR,Oliveira RS,Neder L,Reis RM
Mon May 09 00:00:00 UTC 2016
Expression of Methylthioadenosine Phosphorylase (MTAP) in Pilocytic Astrocytomas.
Pathobiology : journal of immunopathology, molecular and cellular biology
Becker AP,Scapulatempo-Neto C,Menezes WP,Clara C,Machado HR,Oliveira RS,Neder L,Reis RM
Mon May 09 00:00:00 UTC 2016
Characterization and Prognostic Significance of Methylthioadenosine Phosphorylase Deficiency in Nasopharyngeal Carcinoma.
Medicine
He HL,Lee YE,Shiue YL,Lee SW,Chen TJ,Li CF
Tue Dec 01 00:00:00 UTC 2015
Characterization and Prognostic Significance of Methylthioadenosine Phosphorylase Deficiency in Nasopharyngeal Carcinoma.
Medicine
He HL,Lee YE,Shiue YL,Lee SW,Chen TJ,Li CF
Tue Dec 01 00:00:00 UTC 2015
Integrated omic analysis of oropharyngeal carcinomas reveals human papillomavirus (HPV)-dependent regulation of the activator protein 1 (AP-1) pathway.
Molecular & cellular proteomics : MCP
Sepiashvili L,Waggott D,Hui A,Shi W,Su S,Ignatchenko A,Ignatchenko V,Laureano M,Huang SH,Xu W,Weinreb I,Waldron J,O'Sullivan B,Irish JC,Boutros PC,Liu FF,Kislinger T
Mon Dec 01 00:00:00 UTC 2014
Integrated omic analysis of oropharyngeal carcinomas reveals human papillomavirus (HPV)-dependent regulation of the activator protein 1 (AP-1) pathway.
Molecular & cellular proteomics : MCP
Sepiashvili L,Waggott D,Hui A,Shi W,Su S,Ignatchenko A,Ignatchenko V,Laureano M,Huang SH,Xu W,Weinreb I,Waldron J,O'Sullivan B,Irish JC,Boutros PC,Liu FF,Kislinger T
Mon Dec 01 00:00:00 UTC 2014
Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance.
Oncotarget
Li CF,Fang FM,Kung HJ,Chen LT,Wang JW,Tsai JW,Yu SC,Wang YH,Li SH,Huang HY
Sun Nov 30 00:00:00 UTC 2014
Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance.
Oncotarget
Li CF,Fang FM,Kung HJ,Chen LT,Wang JW,Tsai JW,Yu SC,Wang YH,Li SH,Huang HY
Sun Nov 30 00:00:00 UTC 2014
Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance.
Oncotarget
Li CF,Fang FM,Kung HJ,Chen LT,Wang JW,Tsai JW,Yu SC,Wang YH,Li SH,Huang HY
Sun Nov 30 00:00:00 UTC 2014
Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance.
Oncotarget
Li CF,Fang FM,Kung HJ,Chen LT,Wang JW,Tsai JW,Yu SC,Wang YH,Li SH,Huang HY
Sun Nov 30 00:00:00 UTC 2014
Ocular expression and distribution of products of the POAG-associated chromosome 9p21 gene region.
PloS one
Chidlow G,Wood JP,Sharma S,Dimasi DP,Burdon KP,Casson RJ,Craig JE
Sun Jun 15 00:00:00 UTC 2014
Ocular expression and distribution of products of the POAG-associated chromosome 9p21 gene region.
PloS one
Chidlow G,Wood JP,Sharma S,Dimasi DP,Burdon KP,Casson RJ,Craig JE
Sun Jun 15 00:00:00 UTC 2014
Ocular expression and distribution of products of the POAG-associated chromosome 9p21 gene region.
PloS one
Chidlow G,Wood JP,Sharma S,Dimasi DP,Burdon KP,Casson RJ,Craig JE
Sun Jun 15 00:00:00 UTC 2014
Ocular expression and distribution of products of the POAG-associated chromosome 9p21 gene region.
PloS one
Chidlow G,Wood JP,Sharma S,Dimasi DP,Burdon KP,Casson RJ,Craig JE
Sun Jun 15 00:00:00 UTC 2014
The diagnostic value of immunohistochemically detected methylthioadenosine phosphorylase deficiency in malignant pleural mesotheliomas.
Histopathology
Zimling ZG,Jørgensen A,Santoni-Rugiu E
Tue May 01 00:00:00 UTC 2012
The diagnostic value of immunohistochemically detected methylthioadenosine phosphorylase deficiency in malignant pleural mesotheliomas.
Histopathology
Zimling ZG,Jørgensen A,Santoni-Rugiu E
Tue May 01 00:00:00 UTC 2012
Significantly decreased methylthioadenosine phosphorylase expression in malignant melanoma.
The American Journal of dermatopathology
Gambichler T,Scola N,Bechara FG
Mon Oct 01 00:00:00 UTC 2012
Significantly decreased methylthioadenosine phosphorylase expression in malignant melanoma.
The American Journal of dermatopathology
Gambichler T,Scola N,Bechara FG
Mon Oct 01 00:00:00 UTC 2012
Downregulation of methylthioadenosin phosphorylase by homozygous deletion in gastric carcinoma.
Genes, chromosomes & cancer
Kim J,Kim MA,Min SY,Jee CD,Lee HE,Kim WH
Wed Jun 01 00:00:00 UTC 2011
Downregulation of methylthioadenosin phosphorylase by homozygous deletion in gastric carcinoma.
Genes, chromosomes & cancer
Kim J,Kim MA,Min SY,Jee CD,Lee HE,Kim WH
Wed Jun 01 00:00:00 UTC 2011
Downregulation of methylthioadenosin phosphorylase by homozygous deletion in gastric carcinoma.
Genes, chromosomes & cancer
Kim J,Kim MA,Min SY,Jee CD,Lee HE,Kim WH
Wed Jun 01 00:00:00 UTC 2011
Downregulation of methylthioadenosin phosphorylase by homozygous deletion in gastric carcinoma.
Genes, chromosomes & cancer
Kim J,Kim MA,Min SY,Jee CD,Lee HE,Kim WH
Wed Jun 01 00:00:00 UTC 2011
Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma.
The Journal of pathology
Sommer J,Itani DM,Homlar KC,Keedy VL,Halpern JL,Holt GE,Schwartz HS,Coffin CM,Kelley MJ,Cates JM
Thu Apr 01 00:00:00 UTC 2010
Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma.
The Journal of pathology
Sommer J,Itani DM,Homlar KC,Keedy VL,Halpern JL,Holt GE,Schwartz HS,Coffin CM,Kelley MJ,Cates JM
Thu Apr 01 00:00:00 UTC 2010
Homozygous deletion of MTAP gene as a poor prognosticator in gastrointestinal stromal tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Huang HY,Li SH,Yu SC,Chou FF,Tzeng CC,Hu TH,Uen YH,Tian YF,Wang YH,Fang FM,Huang WW,Wei YC,Wu JM,Li CF
Sun Nov 15 00:00:00 UTC 2009
Homozygous deletion of MTAP gene as a poor prognosticator in gastrointestinal stromal tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Huang HY,Li SH,Yu SC,Chou FF,Tzeng CC,Hu TH,Uen YH,Tian YF,Wang YH,Fang FM,Huang WW,Wei YC,Wu JM,Li CF
Sun Nov 15 00:00:00 UTC 2009
