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Positive controls: PC-3M cell lysates, F9, rat large intestine tissue, rat kidney tissue, mouse lung tissue, mouse colon tissue, JAR.
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.
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Protein Aliases: 5'-methylthioadenosine phosphorylase; epididymis luminal protein 249; MeSAdo phosphorylase; MTA phosphorylase; MTAP; MTAPase; S-methyl-5'-thioadenosine phosphorylase
Gene Aliases: 1300019I21Rik; BDMF; c86fus; Cc1-6; DMSFH; DMSMFH; HEL-249; LGMBF; MSAP; MTAP
Molecular Function: nucleotide kinase