In Western blot applications, this antibody detects a band at ~104kDa. A suggested positive control is K562 cell lysate.
PA5-19979 can be used with blocking peptide PEP-0103.
MTBP inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. The protein may play a role in MDM2-dependent TP53/p53 homeostasis in unstressed cells. The protein inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of TP53/p53 and its subsequent degradation.
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Protein Aliases: hdm2; HDMX; hMTBP; MDM2 (mouse double minute 2)-binding protein, 104kD; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa; Mdm2-binding protein; MGC5370; MGC71221
Gene Aliases: MDM2BP; MTBP
UniProt ID: (Human) Q96DY7
Entrez Gene ID: (Human) 27085