|Immunocytochemistry (ICC)||2 µg/ml|
|Immunofluorescence (IF)||2 µg/ml|
|Western Blot (WB)||1µg/ml|
|Western Blot (WB)||See 34 publications below|
|Miscellaneous PubMed (MISC)||See 6 publications below|
|Immunohistochemistry (Frozen) (IHC (F))||See 1 publications below|
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
|Immunocytochemistry (ICC)||See 2 publications below|
|Immunohistochemistry (IHC)||See 2 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Rat , Non-human primate , Human , Mouse , Chicken|
|Host / Isotype||Mouse / IgG2a, kappa|
|Immunogen||Full length native Human Cytochrome C oxidase subunit II|
|Storage buffer||HEPES buffered saline|
|Contains||0.02% sodium azide|
|Storage conditions||4° C, do not freeze|
Cytochrome c oxidase is the fourth complex in the respiratory chain and is responsible for catalyzing the conversion of O2 to H2O. Subunit 2 of the cytochrome c oxidase complex combines with two other subunits (1 and 3) to form a core protein structure that performs many functions of the enzyme. The metallic copper center of this subunit transfers electrons to the heme center of subunit 1, which results in the movement of electrons from cytochrome c to the heme A3 and copper B metallic center of complex IV. Defects in subunit 2 of cytochrome c oxidase can result in COX deficiency, which causes a wide range of symptoms from local myopathy to multiple system pathologies that begin between infancy and adulthood. Abnormalities in this subunit are also associated with tumor development.
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