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Proteintech
MTF1 Polyclonal Antibody
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Product Details
25383-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Fish,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MTF1 Fusion Protein Ag21848 (404-753 aa encoded by BC014454)
Conjugate
Form
Liquid
Concentration
0.24 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VSDVPPSTG NSASLSLPLV LQPGLSEPPQ PLLPASAPSA PPPAPSLGPG SQQAAFGNPP ALLQPPEVPV PHSTQFAANH QEFLPHPQAP QPIVPGLSVV AGASASAAAV ASAVAAPAPP QSTTEPLPAM VQTLPLGANS VLTNNPTITI TPTPNTAILQ SSLVMGEQNL QWILNGATSS PQNQEQIQQA SKVEKVFFTT AVPVASSPGS SVQQIGLSVP VIIIKQEEAC QCQCACRDSA KERASSRRKG CSSPPPPEPS PQAPDGPSLQ LPAQTFSSAP VPGSSSSTLP SSCEQSRQAE TPSDPQTETL SAMDVSEFLS LQSLDTPSNL IPIEALLQGE EEMGLTSSFS K (404-753 aa encoded by BC014454)
Target Information
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Metal regulatory transcription factor 1; metal-regulatory transcription factor 1; metal-responsive transcription factor 1; metalloregulatory transcription factor; MRE-binding transcription factor; MRE-binding transcription factor-1; Transcription factor MTF-1; zinc regulatory factor
Gene Aliases: MTF-1; MTF1; Thyls; ZRF
UniProt ID: (Human) Q14872, (Mouse) Q07243
Entrez Gene ID: (Human) 4520, (Mouse) 17764
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
histone acetyltransferase binding
metal ion binding
nucleic acid binding
C2H2 zinc finger transcription factor
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
response to oxidative stress
response to metal ion
positive regulation of transcription from RNA polymerase II promoter
response to cadmium ion
transcription, DNA-templated
regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
transition metal ion homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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