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Proteintech
MTF2 Polyclonal Antibody
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Product Details
16208-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MTF2 Fusion Protein Ag9182 (187-536 aa encoded by BC010013)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Amount
43.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ADLEWDAGH KTNVQQCYCY CGGPGDWYLK MLQCCKCKQW FHEACVQCLQ KPMLFGDRFY TFICSVCSSG PEYLKRLPLQ WVDIAHLCLY NLSVIHKKKY FDSELELMTY INENWDRLHP GELADTPKSE RYEHVLEALN DYKTMEVSNG IEKKGKKKSV GRPPGPYTRK MIQKTAEPLL DKESISENPT LDLPCSIGRT EGTAHSSNTS DVDFTGASSA KETTSSSISR HYGLSDSRKR TRTGRSWPAA IPHLRRRRGR LPRRALQTQN SEIVKDDEGK EDYQFDELNT EILNNLADQE LQLNHLKNSI TSYFGAAGRI ACGEKYRVLA RRVTLDGKVQ YLVEWEGATA S (187-536 aa encoded by BC010013)
Target Information
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hPCl2; M96A isoform; Metal regulatory transcription factor 2; metal response element DNA-binding protein M96; Metal-response element DNA-binding protein M96; Metal-response element-binding transcription factor 2; mPCl2; polycomb-like 2; Polycomb-like protein 2; putative DNA binding protein; RP5-976O13.1; tudor domain containing 19A; unnamed protein product; Zinc-regulated factor 1; ZiRF1
Gene Aliases: 9230112N11Rik; AA537621; C76717; dJ976O13.2; M96; MTF2; PCL2; RGD1304727; TDRD19A
UniProt ID: (Human) Q9Y483, (Mouse) Q02395
Entrez Gene ID: (Human) 22823, (Rat) 360905, (Mouse) 17765
RNA polymerase II regulatory region sequence-specific DNA binding
transcription corepressor binding
DNA binding
chromatin binding
protein binding
zinc ion binding
metal ion binding
histone H3K36me3 reader activity
molecular_function
methylated histone binding
chromatin/chromatin-binding, or -regulatory protein
chromatin organization
segment specification
stem cell population maintenance
regulation of gene expression, epigenetic
negative regulation of gene expression, epigenetic
stem cell differentiation
cellular response to leukemia inhibitory factor
negative regulation of transcription from RNA polymerase II promoter
biological_process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of histone H3-K27 methylation
positive regulation of histone H3-K27 methylation
chromatin modification
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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