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Immunogen sequence: TNDRFLRKI TIGQAPTEKG HTRTAQFDIS VASEIMAVLA LTTSLEDMRE RLGKMVVASS KKGEPVSAED LGVSGALTVL MKDAIKPNLM QTLEGTPVFV HAGPFANIAH GNSSIIADQI ALKLVGPEGF VVTEAGFGAD IGMEKFFNIK CRYSGLCPHV VVLVATVRAL KMHGGGPTVT AGLPLPKAYI QENLELVEKG FSNLKKQIEN ARMFGIPVVV AVNAFKTDTE SELDLISRLS REHGAFDAVK CTHWAEGGKG ALALAQAVQR AAQAPSSFQL LYDLKLPVED KIRIIAQKIY GADDIELLPE AQHKAEVYTK QGFGNLPICM AKTHLSLSHN PEQKGVPTGF ILPIRDIRAS VGAGFLYPLV GTMSTMPGLP TRPCFYDIDL DPETEQVNGL F (536-935 aa encoded by BC009806)
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.
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Protein Aliases: 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase; C-1-tetrahydrofolate synthase, cytoplasmic; C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed; C1-tetrahydrofolate synthase; C1-THF synthase; cytoplasmic C-1-tetrahydrofolate synthase; Epididymis secretory sperm binding protein; Formyltetrahydrofolate synthetase; methenyltetrahydrofolate; Methenyltetrahydrofolate cyclohydrolase; Methylenetetrahydrofolate dehydrogenase; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
Gene Aliases: Dcs; E430024A07Rik; MTHFC; MTHFD; MTHFD1