Peptide sequence: CMAKTHLSLS HNPEQKGVPT GFILPIRDIR ASVGAGFLYP LVGTMSTMPG
Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Yeast: 79%; Zebrafish: 79%
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.
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Protein Aliases: 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase; C-1-tetrahydrofolate synthase, cytoplasmic; C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed; C1-tetrahydrofolate synthase; C1-THF synthase; cytoplasmic C-1-tetrahydrofolate synthase; Formyltetrahydrofolate synthetase; methenyltetrahydrofolate; Methenyltetrahydrofolate cyclohydrolase; Methylenetetrahydrofolate dehydrogenase; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase; methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase; methylenetetrahydrofolate dehydrogenase 1
Gene Aliases: BOS_11057; Dcs; E430024A07Rik; MTHFC; MTHFD; MTHFD1
Molecular Function: ligase