This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: LNGKEISAQI RARLKNQVTQ LKEQVPGFTP RLAILQVGNR DDSNLYINVK LKAAEEIGIK ATHIKLPRTT TESEVMKYIT SLNEDSTVHG FLVQLPLDSE NSINTEEVIN AIAPEKDVDG LTSINAGRLA RGDLNDCFIP CT
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase; C-1-tetrahydrofolate synthase, cytoplasmic; C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed; C1-tetrahydrofolate synthase; C1-THF synthase; cytoplasmic C-1-tetrahydrofolate synthase; Formyltetrahydrofolate synthetase; Methenyltetrahydrofolate cyclohydrolase; Methylenetetrahydrofolate dehydrogenase; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase; methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase; MTHFC; MTHFD
Gene Aliases: Dcs; E430024A07Rik; MTHFC; MTHFD; MTHFD1
Molecular Function: ligase