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Invitrogen
MTHFD1 Polyclonal Antibody
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Product Details
PA5-82517
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MTHFD1. Recombinant protein control fragment (Product #RP-88920).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AANNLVAAAI DARIFHELTQ TDKALFNRLV PSVNGVRRFS DIQIRRLKRL GIEKTDPTTL TDEEINRFAR LDIDPETITW QRVLDTNDRF LRKITIGQAP TEKGHTRTAQ FDISVASEIM AVLALTTSLE DMRERLGKMV VASSK
Highest antigen sequence indentity to the following orthologs: Mouse - 95%, Rat - 95%.
Target Information
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase; C-1-tetrahydrofolate synthase, cytoplasmic; C1-tetrahydrofolate synthase; C1-THF synthase; cytoplasmic C-1-tetrahydrofolate synthase; Epididymis secretory sperm binding protein; methenyltetrahydrofolate; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase; methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
Gene Aliases: Dcs; E430024A07Rik; MTHFC; MTHFD; MTHFD1
UniProt ID: (Human) P11586, (Mouse) Q922D8, (Rat) P27653
Entrez Gene ID: (Human) 4522, (Mouse) 108156, (Rat) 64300
formate-tetrahydrofolate ligase activity
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
methylenetetrahydrofolate dehydrogenase (NAD+) activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
protein binding
ATP binding
nucleotide binding
catalytic activity
oxidoreductase activity
hydrolase activity
ligase activity
histidine biosynthetic process
neutrophil homeostasis
neural tube closure
purine nucleotide biosynthetic process
methionine metabolic process
one-carbon metabolic process
heart development
serine family amino acid metabolic process
serine family amino acid biosynthetic process
methionine biosynthetic process
10-formyltetrahydrofolate biosynthetic process
transsulfuration
tetrahydrofolate interconversion
folic acid metabolic process
embryonic neurocranium morphogenesis
embryonic viscerocranium morphogenesis
oxidation-reduction process
somite development
metabolic process
cellular amino acid biosynthetic process
folic acid-containing compound biosynthetic process
nucleotide metabolic process
tetrahydrofolate metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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