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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1-5 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
MTHFD2 (NP_001035499.1, 1 a.a. approximately 248 a.a) full-length human protein. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
See Label |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4 |
Contains |
no preservative |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Sequence of this protein is as follows: MKPASISEEE LLNLINKLNN DDNVDGLLVQ LPLPEHIDER RICNAVSPDK DVDGFHVINV GRMCLDQYSM LPATPWGVWE IIKRTGIPTL GKNVVVAGRS KNVGMPIAML LHTDGAHERP GGDATVTISH RYTPKEQLKK HTILADIVIS AAGIPNLITA DMIKEGAAVI DVGINRVHDP VTAKPKLVGD VDFEGVRQKA GYITPVPGGV GPMTVAMLMK NTIIAAKKVL RLEEREVLKS KELGVATN
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Methenyltetrahydrofolate cyclohydrolase; NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase; NAD-dependent methylenetetrahydrofolate dehydrogenase
Gene Aliases: MTHFD2; NMDMC
UniProt ID: (Human) P13995
Entrez Gene ID: (Human) 10797
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