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Product Details
13924-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MTM1 Fusion Protein Ag4940 (1-362 aa encoded by BC030779)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MASASTSKY NSHSLENESI KRTSRDGVNR DLTEAVPRLP GETLITDKEV IYICPFNGPI KGRVYITNYR LYLRSLETDS SLILDVPLGV ISRIEKMGGA TSRGENSYGL DITCKDMRNL RFALKQEGHS RRDMFEILTR YAFPLAHSLP LFAFLNEEKF NVDGWTVYNP VEEYRRQGLP NHHWRITFIN KCYELCDTYP ALLVVPYRAS DDDLRRVATF RSRNRIPVLS WIHPENKTVI VRCSQPLVGM SGKRNKDDEK YLDVIRETNK QISKLTIYDA RPSVNAVANK ATGGGYESDD AYHNAELFFL DIHNIHVMRE SLKKVKDIVY PNVEESHWLS SLESTHWLEH IKLVLTGAIQ VAD (1-362 aa encoded by BC030779)
Target Information
Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Myotubularin; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase; X-linked myotubular myopathy gene 1
Gene Aliases: AF073996; CG2; CNM; mKIAA4176; Mtm; MTM1; MTMX; XLMTM
UniProt ID: (Human) Q13496, (Rat) Q6AXQ4, (Mouse) Q9Z2C5
Entrez Gene ID: (Human) 4534, (Rat) 288762, (Mouse) 17772
phosphatidylinositol-3-phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
protein binding
intermediate filament binding
phosphatidylinositol binding
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
molecular_function
hydrolase activity
phosphatase activity
phosphatase
protein dephosphorylation
phosphatidylinositol biosynthetic process
endosome to lysosome transport
protein transport
negative regulation of TOR signaling
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
peptidyl-tyrosine dephosphorylation
regulation of vacuole organization
intermediate filament organization
muscle cell cellular homeostasis
phosphatidylinositol dephosphorylation
mitochondrion distribution
positive regulation of skeletal muscle tissue growth
negative regulation of protein kinase B signaling
mitochondrion morphogenesis
negative regulation of autophagosome assembly
biological_process
lipid metabolic process
transport
dephosphorylation
Performance Guarantee
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