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Immunogen sequence: SHQEQLSSV PDLTHGEEDI GKRGNNRNGQ LLENPRFGKM PLELVRKPIS QSQISEFSFL GSNWDSFQGM VTSFPSGEAT PRRLLSYGCC SKRPNSKQMR ATGPCFGGQW AQREGVKSPV CSSHSNGHCT GPGGKNQMWL SSHPKQVSST KPVPLNCPSP VPPLYLDDDG LPFPTDVIQH RLRQIEAGYK QEVEQLRRQV RELQMRLDIR HCCAPPAEPP MDYEDDFTCL KESDGSDTED FGSDHSEDCL SEASWEPVDK KETEVTRWVP DHMASHCYNC DCEFWLAKRR HHCRNCGNVF CAGCCHLKLP IPDQQLYDPV LVCNSCYEHI QVSRARELMS QQLKKPIATA SS (845-1195 aa encoded by BC035609)
MTMR, a member of the myotubularin family, encodes an intracellular protein of 1, 195 amino acids, and shares approximately 47% sequence identity with MTMR3, spiking to over 70% identity in the catalytic domain and the double zinc finger (FYVE) motif. PCR analysis detects expression of MTMR4 in all human tissues examined except lung, small intestine, stomach, salivary gland, adrenal gland, and uterus. Subcellular localization of MTMR4 in transfected HeLa cells showed a perinuclear distribution, similar to that seen with MTMR3. MTMR4 dephosphorylates para-nitrophenylphosphate and phosphatidylinositol 3-phosphate.
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Protein Aliases: DKFZp781E194; FYVE domain-containing dual specificity protein phosphatase 2; FYVE zinc finger phosphatase; FYVE-DSP2; MGC163449; MGC163451; MTMR7; Myotubularin-related protein 4; Zinc finger FYVE domain-containing protein 11; zinc finger, FYVE domain containing 11
Gene Aliases: AA596759; ESTM44; FYVE-DSP2; KIAA0647; mKIAA0647; MTMR4; ZFYVE11
UniProt ID: (Human) Q9NYA4, (Mouse) Q91XS1
Entrez Gene ID: (Human) 9110, (Mouse) 170749
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