|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 1155-1187 amino acids from the C-terminal region of human MTMR4|
|Purification||Size-exclusion - Dialysis, Ammonium sulfate precipitation|
|Contains||0.09% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:50|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
MTMR, a member of the myotubularin family, encodes an intracellular protein of 1,195 amino acids, and shares approximately 47% sequence identity with MTMR3, spiking to over 70% identity in the catalytic domain and the double zinc finger (FYVE) motif. PCR analysis detects expression of MTMR4 in all human tissues examined except lung, small intestine, stomach, salivary gland, adrenal gland, and uterus. Subcellular localization of MTMR4 in transfected HeLa cells showed a perinuclear distribution, similar to that seen with MTMR3. MTMR4 dephosphorylates para-nitrophenylphosphate and phosphatidylinositol 3-phosphate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma.
PA5-13711 was used in immunohistochemistry - paraffin section determine PTP family expression in diffuse glioma subtypes
|Bourgonje AM,Verrijp K,Schepens JT,Navis AC,Piepers JA,Palmen CB,van den Eijnden M,Hooft van Huijsduijnen R,Wesseling P,Leenders WP,Hendriks WJ||Acta neuropathologica communications (4:null)||2016|