Immunogen sequence: RCGQLDGDPK EVSPVFTQFL ECVWHLTEQF PQAFEFSEAF LLQIHEHIHS CQFGNFLGNC QKEREELKLK EKTYSLWPFL LEDQKKYLNP LYSSESHRFT VLEPNTVSFN FKFWRNMYHQ FDRTLHPRQS VFNIIMNMNE QNKQLEKDIK DLESKIKQRK NKQTDGILTK ELLHSVHPES PNLKTSLCFK EQTLLPVNDA LRTIEGSSPA DNRYSEYAEE FSKSEPAVVS LEYGVARMTC; Positive Samples: HepG2, HeLa, 293T, Mouse heart, Mouse brain, Mouse lung, Mouse spleen, Mouse testis, Rat heart; Cellular Location: Nucleus envelope
Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3. 1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: mtmr6; Myotubularin-related protein 6; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase
Gene Aliases: 4022440C11Rik; AI428804; AU041072; MTMR6