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MTNR1B Polyclonal Antibody
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FIGURE: 1 / 1
MTNR1B Antibody (BS-21511R) in WB
Lane 1:Mouse Cerebrum tissue lysates; Lane 2: Mouse Cerebellum tissue lysates probed with MTNR1B Polyclonal Antibody, Unconjugated (bs-21511R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
BS-21511R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human MTNR1B (271-364).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G-protein coupled receptor; G-protein coupled receptor MTNR1B; Mel-1b melatonin receptor; mel1b receptor; melatonin receptor MEL1B; MT2; MT2 melatonin receptor
Gene Aliases: FGQTL2; MEL-1B-R; Mel1b; MT2
UniProt ID: (Human) P49286
Entrez Gene ID: (Human) 4544, (Mouse) 244701
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
chemical synaptic transmission
negative regulation of cGMP-mediated signaling
glucose homeostasis
positive regulation of circadian rhythm
camera-type eye development
negative regulation of neuron apoptotic process
negative regulation of vasoconstriction
positive regulation of circadian sleep/wake cycle, non-REM sleep
negative regulation of insulin secretion
regulation of insulin secretion
negative regulation of cytosolic calcium ion concentration
negative regulation of transmission of nerve impulse
positive regulation of transmission of nerve impulse
regulation of neuronal action potential
circadian rhythm
negative regulation of delayed rectifier potassium channel activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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