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Proteintech
MTRR Polyclonal Antibody
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Product Details
26944-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MTRR Fusion Protein Ag25678 (376-725 aa encoded by BC109216)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TKKKGATLP QHIPAGCSLQ FIFTWCLEIR AIPKKAFLRA LVDYTSDSAE KRRLQELCSK QGAADYSRFV RDACACLLDL LLAFPSCQPP LSLLLEHLPK LQPRPYSCAS SSLFHPGKLH FVFNIVEFLS TATTEVLRKG VCTGWLALLV ASVLQPNIHA SHEDSGKALA PKISISPRTT NSFHLPDDPS IPIIMVGPGT GIAPFIGFLQ HREKLQEQHP DGNFGAMWLF FGCRHKDRDY LFRKELRHFL KHGILTHLKV SFSRDAPVGE EEAPAKYVQD NIQLHGQQVA RILLQENGHI YVCGDAKNMA KDVHDALVQI ISKEVGVEKL EAMKTLATLK EEKRYLQDIW S (376-725 aa encoded by BC109216)
Target Information
Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing); AqCbl reductase; Aquacobalamin reductase; Methionine synthase reductase; methionine synthase reductase, mitochondrial; MGC129643; MSR
Gene Aliases: cblE; MSR; MTRR
UniProt ID: (Human) Q9UBK8
Entrez Gene ID: (Human) 4552
NADPH-hemoprotein reductase activity
protein binding
FMN binding
oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
[methionine synthase] reductase activity
aquacobalamin reductase (NADPH) activity
flavin adenine dinucleotide binding
NADP binding
NADPH binding
FAD binding
oxidoreductase
sulfur amino acid metabolic process
DNA methylation
methionine metabolic process
methionine biosynthetic process
cobalamin metabolic process
methylation
S-adenosylmethionine cycle
homocysteine catabolic process
folic acid metabolic process
oxidation-reduction process
negative regulation of cystathionine beta-synthase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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