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Product Details
PA5-112617
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Metastasis suppressor protein 1 protein (616-730AA)
Conjugate
Form
Liquid
Concentration
3.84 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2867352
Target Information
Metastasis suppressor protein 1 (MTSS1) [MIM, "missing in metastasis"], was first discovered as missing transcripts from metastatic bladder and prostate cancer cells. MTSS1 is a 755 amino acid protein, having multidomain and scaffolding function. It has a proline-rich/SH3 binding region and a serine-rich region with EGF or PDGF/Src consensus sites. It contains anactin-binding Wiskott-Aldrich syndrome protein homology-2 motif (WH2) at the C-terminus while the N-terminal IMD domain (IRSp53-MIM domain) interact with membranes and bundle actin filament. The WH2 domain binds to actin monomers and plays an important role in actin cytoskeleton reorganization. Recently, MIM was found to interact with cortactin via SH3 domains. In addition, MTSS1 enhanced cortactin- and Arp2/3-dependent actin polymerization. It is thus involved in cell motility and morphogenesis and also interacts with sonic hedgehog/Gli signaling in epidermal cells. MTSS1 acts as an important regulator of cell growth and development and is known to express in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Metastasis suppressor protein 1; Metastasis suppressor YGL-1; Missing in metastasis protein; Protein MTSS 1
Gene Aliases: KIAA0429; MIM; MIMA; MIMB; MTSS1
UniProt ID: (Human) O43312
Entrez Gene ID: (Human) 9788
positive regulation of defense response to virus by host
movement of cell or subcellular component
plasma membrane organization
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
microspike assembly
actin cytoskeleton organization
negative regulation of epithelial cell proliferation
renal tubule morphogenesis
cellular response to fluid shear stress
glomerulus morphogenesis
nephron tubule epithelial cell differentiation
xenophagy
epithelial cell proliferation involved in renal tubule morphogenesis
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