Keep as concentrated solution.
Positive Control: MCF-7.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM and EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. MUC1 is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through several intermediate forms generated by proteolysis, and sequential addition and processing of numerous O-linked glycans that are heavily sialylated. MUC1 is highly polymorphic and each allele encodes a product that contains a different number of repeats (between 30 and 90) leading to large differences in molecular weight of the protein. MUC1 is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells, and is expressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. Overexpression, aberrant intracellular localization, and changes in glycosylation of the MUC1 protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of the MUC1 gene have been reported, but the full-length nature of only some has been determined. Transgenic MUC-1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Breast carcinoma-associated antigen DF3; breast carcinoma-associated antigen DF3 antibody; CA 15-3; CA 153 antibody; Cancer antigen 15-3; Carcinoma-associated mucin; carcinoma-associated mucin antibody; CD227; CD227 antibody; cell surface associated antibody; DF3 antigen; DF3 antigen antibody; EMA; EMA antibody; Episialin; episialin antibody; H23 antigen; H23 antigen antibody; H23AG; H23AG antibody; KL-6; KL-6 antibody; KL6 antibody; Krebs von den Lungen-6; MAM6 antibody; Medullary cystic kidney disease, autosomal dominant; MUC-1; MUC-1 antibody; MUC-1/SEC antibody; MUC-1/X antibody; MUC1 antibody; MUC1-beta; MUC1-CT; MUC1-NT; MUC1/SEC antibody; MUC1/X antibody; MUC1/ZD antibody; mucin 1; mucin 1, transmembrane; Mucin-1; mucin-1 antibody; Mucin-1 subunit alpha; Mucin-1 subunit beta; Peanut-reactive urinary mucin; peanut-reactive urinary mucin antibody; PEM; PEM antibody; PEMT; PEMT antibody; Polymorphic epithelial mucin; polymorphic epithelial mucin antibody; PUM; PUM antibody; transmembrane antibody; tumor associated epithelial mucin; tumor associated epithelial mucin antibody; Tumor-associated epithelial membrane antigen; tumor-associated epithelial membrane antigen antibody; Tumor-associated mucin; tumor-associated mucin antibody
Gene Aliases: ADMCKD; ADMCKD1; CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1; MUC1/ZD; PEM; PEMT; PUM
UniProt ID: (Human) P15941
Entrez Gene ID: (Human) 4582