Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Nearly all mucosal surfaces are protected by mucin transmembrane glycoproteins, from bronchioles to corneas to reproductive tracts. Mucin 4 (MUC4) is membrane-bound and is important in protecting and lubricating. MUC4 expression is erroneous in many carcinomas and sarcomas, including fibromyoxoid sarcoma and pancreatic adenocarcinoma. Immunohistochemical staining for MUC4 has been discussed as a potential biomarker for detection of these cancers. MUC4 seems to be most predominantly affected in Asian diseases – Taiwanese infertility and endometriosis, as well as gallstone formation in Chinese men, are connected to MUC4, where similar diseases in other populations do not share these MUC4 mutations. Because MUC4 is so important in mucosal surface protection, it is not surprising that it has been implicated as failing in many metastatic cancer invasions.
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Protein Aliases: Ascites sialoglycoprotein; Ascites sialoglycoprotein 1; Ascites sialoglycoprotein 2; ASGP; ASGP-1; ASGP-2; HSA276359; MUC-4; mucin 4; mucin 4, ASGP; mucin 4, tracheobronchial; Mucin-4; Mucin-4 alpha chain; Mucin-4 beta chain; Pancreatic adenocarcinoma mucin; Testis mucin; tracheobronchial; Tracheobronchial mucin
Gene Aliases: 4933405I11Rik; ASGP; HSA276359; MUC-4; MUC4
UniProt ID: (Human) Q99102