Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:300-1:1,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
MUL1 Fusion Protein Ag9119 (27-239 aa encoded by BC010101) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.3 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: SVYRQKARV SQELKGAKKV HLGEDLKSIL SEAPGKCVPY AVIEGAVRSV KETLNSQFVE NCKGVIQRLT LQEHKMVWNR TTHLWNDCSK IIHQRTNTVP FDLVPHEDGV DVAVRVLKPL DSVDLGLETV YEKFHPSIQS FTDVIGHYIS GERPKGIQET EEMLKVGATL TGVGELVLDN NSVRLQPPKQ GMQYYLSSQD FDSLLQRQES SVRL (27-239 aa encoded by BC010101)
E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 SUMO-protein ligase MUL1; E3 ubiquitin ligase; E3 ubiquitin-protein ligase MUL1; Growth inhibition and death E3 ligase; mitochondria-anchored protein ligase; mitochondrial E3 ubiquitin ligase 1; mitochondrial ubiquitin ligase activator of NF-kB; Mitochondrial ubiquitin ligase activator of NFKB 1; Mitochondrial-anchored protein ligase; Protein Hades; Putative NF-kappa-B-activating protein 266; RING finger protein 218; RING-type E3 ubiquitin transferase NFKB 1; RP11-401M16.2
Gene Aliases: 0610009K11Rik; AV000801; C1orf166; GIDE; MAPL; MUL1; MULAN; RGD1309944; RNF218
UniProt ID: (Human) Q969V5, (Mouse) Q8VCM5
Entrez Gene ID: (Human) 79594, (Mouse) 68350, (Rat) 298576
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