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Invitrogen

MUL1 Polyclonal Antibody

View all (7) MUL1 antibodies
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Product Details

PA5-100877

Applications Tested Dilution Publications

Western Blot (WB)

 1:500-1:2,000 -
Product Specifications

Species Reactivity

 Human, Mouse

Host/Isotype

 Rabbit / IgG

Class

 Polyclonal

Type

 Antibody

Immunogen

A synthesized peptide derived from human MUL1(Accession Q969V5), corresponding to amino acid residues E200-L229.
View antigen

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 1 mg/mL

Purification

 Affinity chromatography

Storage buffer

 PBS, pH 7.4, with 50% glycerol, 150mM NaCl

Contains

 0.02% sodium azide

Storage conditions

 -20°C

RRID

AB_2850374

Target Information

E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E3 SUMO-protein ligase MUL1; E3 ubiquitin ligase; E3 ubiquitin-protein ligase MUL1; Growth inhibition and death E3 ligase; mitochondria-anchored protein ligase; mitochondrial E3 ubiquitin ligase 1; mitochondrial ubiquitin ligase activator of NF-kB; Mitochondrial ubiquitin ligase activator of NFKB 1; Mitochondrial-anchored protein ligase; Protein Hades; Putative NF-kappa-B-activating protein 266; RING finger protein 218; RING-type E3 ubiquitin transferase NFKB 1; RP11-401M16.2

Gene Aliases: 0610009K11Rik; AV000801; C1orf166; GIDE; MAPL; MUL1; MULAN; RNF218

UniProt ID: (Human) Q969V5, (Mouse) Q8VCM5

Entrez Gene ID: (Human) 79594, (Mouse) 68350

Function(s)
mitochondrial fission apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process mitochondrion organization activation of JUN kinase activity negative regulation of mitochondrial fusion regulation of mitochondrion organization protein ubiquitination negative regulation of cell growth regulation of protein stability protein destabilization positive regulation of protein sumoylation positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of innate immune response negative regulation of defense response to virus by host protein stabilization mitochondrion localization regulation of mitochondrial membrane potential negative regulation of protein kinase B signaling negative regulation of type I interferon-mediated signaling pathway cellular response to exogenous dsRNA negative regulation of chemokine (C-C motif) ligand 5 production positive regulation of mitochondrial fission regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway positive regulation of dendrite extension protein sumoylation
Process(es)
ubiquitin-protein transferase activity signal transducer activity protein binding zinc ion binding ligase activity SUMO transferase activity ubiquitin protein ligase binding identical protein binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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