P65 NLS is a transcription factor belonging to NF-kappa B family with the N-terminal Rel homology domain of the NF-kB family, a C-terminal transcription activation domain and a nuclear receptor interaction motif (LXXLL). p65 is a part of the nuclear localization signal (NLS) polypeptide of NF-kB (p50/p65) heterodimer. IkBa the most abundant IkB interacts with active NF-kB p65 homodimers and inactivates their transcriptional potential by trapping them in the cytoplasm and through stable complex formation. It is ubiquitously expressed in most of the tissues.
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Protein Aliases: C1orf166; E3 SUMO-protein ligase MUL1; E3 ubiquitin ligase; E3 ubiquitin-protein ligase MUL1; GIDE; Growth inhibition and death E3 ligase; MAPL; mitochondria-anchored protein ligase; mitochondrial E3 ubiquitin ligase 1; mitochondrial ubiquitin ligase activator of NF-kB; Mitochondrial ubiquitin ligase activator of NFKB 1; Mitochondrial-anchored protein ligase; MULAN; Putative NF-kappa-B-activating protein 266; RING finger protein 218; RING-type E3 ubiquitin transferase NFKB 1; RNF218; RP11-401M16.2
Gene Aliases: 0610009K11Rik; AV000801; BOS_2439; C1orf166; GIDE; MAPL; MUL1; MULAN; RNF218