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Invitrogen
MUL1 Polyclonal Antibody
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Product Details
PA5-29550
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly,
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human MUL1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.97 mg/mL
Amount
97 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: A431, A431 membrane extract.
Predicted reactivity: Mouse (90%), Rat (91%), Rhesus Monkey (100%), Bovine (82%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AT15655p; CG1134-PA; CG1134-PB; E3 SUMO-protein ligase MUL1; E3 ubiquitin ligase; E3 ubiquitin-protein ligase MUL1; Growth inhibition and death E3 ligase; mitochondria-anchored protein ligase; mitochondrial E3 ubiquitin ligase 1; Mitochondrial E3 ubiquitin protein ligase 1; mitochondrial E3 ubiquitin protein ligase 1 homologue; Mitochondrial E3 ubiquitin protein transferase 1; mitochondrial ubiquitin ligase activator of NF-kB; Mitochondrial ubiquitin ligase activator of NFKB 1; Mitochondrial-anchored protein ligase; Mul1-PA; Mul1-PB; Protein Hades; Putative NF-kappa-B-activating protein 266; RING finger protein 218; RING-type E3 ubiquitin transferase NFKB 1; RP11-401M16.2; unnamed protein product
Gene Aliases: C1orf166; CG1134; Dmel\CG1134; Dmel_CG1134; GIDE; MAPL; MUL1; MULAN; RNF218
UniProt ID: (Human) Q969V5, (Fruit fly) Q9VZJ9
Entrez Gene ID: (Human) 79594, (Fruit fly) 38472
protein polyubiquitination
mitochondrial fission
apoptotic process
positive regulation of metabolic process
negative regulation of mitochondrial fusion
regulation of mitochondrion organization
protein ubiquitination
protein sumoylation
regulation of anatomical structure morphogenesis
regulation of protein stability
protein destabilization
positive regulation of protein sumoylation
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of innate immune response
negative regulation of defense response to virus by host
protein stabilization
positive regulation of developmental process
mitochondrion localization
regulation of mitochondrial membrane potential
negative regulation of protein kinase B signaling
negative regulation of type I interferon-mediated signaling pathway
cellular response to exogenous dsRNA
negative regulation of chemokine (C-C motif) ligand 5 production
positive regulation of mitochondrial fission
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of dendrite extension
positive regulation of type 2 mitophagy
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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