FIGURE: 1 / 1
Immunogen sequence: LTITTLYCCR RRKQWKNKKR ESAAVTLTTL PSELLLDRLH PNPMYQRMPL LLNPKLLSLE YPRNNIEYVR DIGEGAFGRV FQARAPGLLP YEPFTMVAVK MLKEEASADM QADFQREAAL MAEFDNPNIV KLLGVCAVGK PMCLLFEYMA YGDLNEFLRS MSPHTVCSLS HSDLSMRAQV SSPGPPPLSC AEQLCIARQV AAGMAYLSER KFVHRDLATR NCLVGENMVV KIADFGLSRN IYSADYYKAN ENDAIPIRWM PPESIFYNRY TTESDVWAYG VVLWEIFSYG LQPYYGMAHE EVIYYVRDGN ILSCPENCPV ELYNLMRLCW SKLPADRPSF TSIHRILERM CERAEGTVSV; Positive Samples: SW480; Cellular Location: Cell junction, Single-pass type I membrane protein, postsynaptic cell membrane, synapse
MUSK plays an important and selective role in many aspects of skeletal muscle development and function through the initial step of postsynaptic differentiation and formation of end-plate bands in cooperation with Rapsyn. Communication between cells is often mediated by receptors on the surface of the target cell that are triggered by specific ligands released by other cells. Receptor tyrosine kinase activity is strictly regulated by the binding of the appropriate ligand to the extracellular active site of the receptor. MuSK has been shown to be part of the agrin signaling complex and plays an important role in the development and architectural maintenance of the neuromuscular junction.
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Protein Aliases: MGC126323; MGC126324; muscle localized kinase 2; muscle, skeletal receptor tyrosine protein kinase; Muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific protein kinase secretory isoform; muscle-specific tyrosine protein kinase receptor; Muscle-specific tyrosine-protein kinase receptor; MuSK; RP23-170A3.1
Gene Aliases: Mdk4; Mlk; Musk; Nsk1; Nsk2; Nsk3
UniProt ID: (Mouse) Q61006
Entrez Gene ID: (Mouse) 18198
Molecular Function: transmembrane signal receptor