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Invitrogen
MUTYH Polyclonal Antibody
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Product Details
PA5-18267
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (HISTDAHSLNSAAQ) corresponding to the C-terminus amino acids of MUTYH (aa 533-546).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
MYH (mutY homolog (E. coli )) is a DNA glycosylase mismatch repair enzyme that in conjunction with mutM (OGG1), cleaves adenine residues paired with either oxidized (8-hydroxyguanines) or non-modified guanines in order to correct A/G and A/C mismatches. Repair of most modified and mispaired bases in the genome is initiated by DNA glycosylases, which bind and cleave N-glycosyl bonds to initiate base excision repair. MYH is crucial for the avoidance of mutations resulting from oxidative DNA damage. Multiple N-terminal splice variants of MYH exist in mammalian cells. Increasing levels of MYH in A549 cells exposed to oxygen and infrared radiation leads to improvements in cell survival. Biallelic MYH germ-line mutations predispose humans to colorectal adenomas and carcinomas. MYH is abundant in neurons where mitochondrial genomes exposed to reactive oxygen species (ROS) that damage DNA must maintain integrity over the entire mammalian life span.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A/G-specific adenine DNA glycosylase; Adenine DNA glycosylase; hMYH; MGC4416; MutY homolog; mutY homolog (E. coli) isoform MUTYH_1; mutY homolog (E. coli) isoform MUTYH_3; mutY-like protein; OTTHUMP00000009098; OTTHUMP00000009102; RP4-534D1.2; unnamed protein product
Gene Aliases: MUTYH; MYH
UniProt ID: (Human) Q9UIF7
Entrez Gene ID: (Human) 4595
purine-specific mismatch base pair DNA N-glycosylase activity
DNA binding
catalytic activity
protein binding
hydrolase activity
hydrolase activity, acting on glycosyl bonds
DNA N-glycosylase activity
oxidized purine DNA binding
MutLalpha complex binding
MutLbeta complex binding
MutSalpha complex binding
MutSbeta complex binding
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
adenine/guanine mispair binding
metal ion binding
iron-sulfur cluster binding
4 iron, 4 sulfur cluster binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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