PA5-27212 targets MVP/LRP in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-27212 immunogen is recombinant fragment corresponding to a region within amino acids 646 and 877 of Human MVP/LRP.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
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Protein Aliases: Lung resistance-related protein; Major vault protein; MVP; testicular secretory protein Li 30; VAULT1
Gene Aliases: 2310009M24Rik; LRP; MVP; VAULT1