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Invitrogen
MVP Polyclonal Antibody
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FIGURE: 1 / 9
MVP Antibody (PA5-79710) in ICC/IF
Immunocytochemistry analysis of MVP using anti-MVP antibody (Product # PA5-79710) . MVP was detected in a section of A431 cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and then incubated with 2μg/mL rabbit anti-MVP antibody (Product # PA5-79710) overnight at 4°C. DyLight®488 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained with DAPI. Visualize... View More
Product Details
PA5-79710
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived human MVP recombinant protein (Position: A2-H259).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human placenta tissue, human HepG2 whole cell, human A549 whole cell, human PANC-1 whole cell, human SGC-7901 whole cell, human MDA-MB-231 whole cell, rat spleen tissue, rat lung tissue, rat kidney tissue, mouse spleen tissue, mouse lung tissue, mouse kidney tissue. IHC: human intestinal cancer tissue, mouse small intestine tissue, rat small intestine tissue, human lung cancer tissue. ICC/IF: A431 cell. Flow: Hela cell, U-87 cell.
Target Information
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: lrp; Lung resistance-related protein; Major vault protein; MVP; MVP1; Testicular Secretory Protein Li 30; unnamed protein product; VAULT1; vRNP
Gene Aliases: 2310009M24Rik; LRP; MVP; VAULT1
UniProt ID: (Human) Q14764, (Rat) Q62667, (Mouse) Q9EQK5
Entrez Gene ID: (Human) 9961, (Rat) 64681, (Mouse) 78388
cell proliferation
protein transport
negative regulation of protein autophosphorylation
ERBB signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
mRNA transport
negative regulation of protein tyrosine kinase activity
protein activation cascade
negative regulation of signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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